Effects of sodium and potassium supplementation on endothelial function: a fully controlled dietary intervention study
| Autor: | Lieke Gijsbers, Johanna M. Geleijnse, Stephan J. L. Bakker, Casper G. Schalkwijk, Yvo H.A.M. Kusters, James I Dower, Peter C. H. Hollman |
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| Přispěvatelé: | Groningen Institute for Organ Transplantation (GIOT), Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Interne Geneeskunde, Promovendi CD, RS: CARIM - R3 - Vascular biology |
| Rok vydání: | 2015 |
| Předmět: |
Male
ARTERIAL VASCULAR REACTIVITY Novel Foods & Agrochains Brachial Artery Nutrition and Disease Medicine (miscellaneous) Blood Pressure BLOOD-PRESSURE Vasomotion Novel Foods & Agroketens INCREASE Voeding en Ziekte BU Toxicology Novel Foods & Agrochains Endothelial dysfunction Brachial artery Aged 80 and over Cross-Over Studies Nutrition and Dietetics Endothelin-1 biology BU Toxicology Middle Aged RANDOMIZED CONTROLLED-TRIAL Vasodilation Flow-mediated dilation BU Toxicologie Novel Foods & Agroketens Female Adult medicine.medical_specialty BU Toxicologie Randomised controlled trials Placebo Double-Blind Method BRACHIAL-ARTERY medicine.artery Internal medicine medicine Humans Interleukin 8 Aged VLAG Global Nutrition Inflammation Wereldvoeding Dose-Response Relationship Drug HYPERTENSION business.industry Interleukin-8 Sodium C-reactive protein Potassium Dietary Sodium Dietary Endothelial function ADULTS medicine.disease Endothelin 1 DYSFUNCTION Diet Endocrinology Blood pressure Regional Blood Flow Dietary Supplements SALT DIET Potassium biology.protein Endothelium Vascular business Biomarkers |
| Zdroj: | British Journal of Nutrition, 114(9), 1419-1426. Cambridge University Press British Journal of Nutrition, 114(9), 1419-1426 British Journal of Nutrition 114 (2015) 9 |
| ISSN: | 1475-2662 0007-1145 |
| Popis: | High Na and low K intakes have adverse effects on blood pressure, which increases the risk for CVD. The role of endothelial dysfunction and inflammation in this pathophysiological process is not yet clear. In a randomised placebo-controlled cross-over study in untreated (pre)hypertensives, we examined the effects of Na and K supplementation on endothelial function and inflammation. During the study period, subjects were provided with a diet that contained 2·4 g/d of Na and 2·3 g/d of K for a 10 460 kJ (2500 kcal) intake. After 1-week run-in, subjects received capsules with supplemental Na (3·0 g/d), supplemental K (2·8 g/d) or placebo, for 4 weeks each, in random order. After each intervention, circulating biomarkers of endothelial function and inflammation were measured. Brachial artery flow-mediated dilation (FMD) and skin microvascular vasomotion were assessed in sub-groups of twenty-two to twenty-four subjects. Of thirty-seven randomised subjects, thirty-six completed the study. Following Na supplementation, serum endothelin-1 was increased by 0·24 pg/ml (95 % CI 0·03, 0·45), but no change was seen in other endothelial or inflammatory biomarkers. FMD and microvascular vasomotion were unaffected by Na supplementation. K supplementation reduced IL-8 levels by 0·28 pg/ml (95 % CI 0·03, 0·53), without affecting other circulating biomarkers. FMD was 1·16 % (95 % CI 0·37, 1·96) higher after K supplementation than after placebo. Microvascular vasomotion was unaffected. In conclusion, a 4-week increase in Na intake increased endothelin-1, but had no effect on other endothelial or inflammatory markers. Increased K intake had a beneficial effect on FMD and possibly IL-8, without affecting other circulating endothelial or inflammatory biomarkers. |
| Databáze: | OpenAIRE |
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