Tunable biohybrid hydrogels from coacervation of hyaluronic acid and PEO-based block copolymers
| Autor: | Daniel Klinger, Mathijs F. J. Mabesoone, Ilka E. Paulus, Jeffrey D. Gopez |
|---|---|
| Přispěvatelé: | Macro-Organic Chemistry |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Polymers and Plastics
Biocompatibility 02 engineering and technology macromolecular substances engineering.material 010402 general chemistry 01 natural sciences complex mixtures chemistry.chemical_compound Hyaluronic acid hyaluronic acid Materials Chemistry Copolymer Physical and Theoretical Chemistry coacervates Coacervate Chemistry Cationic polymerization technology industry and agriculture Biodegradation 021001 nanoscience & nanotechnology 0104 chemical sciences block copolymers Chemical engineering Self-healing hydrogels engineering Biopolymer 600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie Therapeutik 0210 nano-technology biomaterials |
| Zdroj: | Journal of Polymer Science, 58(9), 1276-1287. Wiley |
| ISSN: | 2642-4150 |
| Popis: | Accurately tuning the macroscopic properties of biopolymer-based hydrogels remains challenging due to the ill-defined molecular architecture of the natural building blocks. Here, we report a biohybrid coacervate hydrogel, combining the biocompatibility and biodegradability of naturally occurring hyaluronic acid (HA) with the tunability of a synthetic polyethylene oxide (PEO) -based ABA-triblock copolymer. Coacervation of the cationic ammonium or guanidinium-functionalized copolymer A-blocks with the anionic HA leads to hydrogel formation. Both mechanical properties and water content of the self-healing hydrogels can be controlled independently by altering the copolymer structure. By controlling the strength of the interaction between the polymer network and small-molecule cargo, both release rate and maximum release are controlled. Finally, we show that coacervation of HA and the triblock copolymer leads to increased biostability upon exposure to hyaluronidase. We envision that noncovalent crosslinking of HA hydrogels through coacervation is an attractive strategy for the facile synthesis of tunable hydrogels for biomedical applications. |
| Databáze: | OpenAIRE |
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