Clinical associations with immature breathing in preterm infants: part 2—periodic breathing
| Autor: | Robert A. Sinkin, J. Randall Moorman, John Kattwinkel, Mary Mohr, John B. Delos, Karen D. Fairchild, Douglas E. Lake, Manisha Patel |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Time Factors Gestational Age Signs and symptoms Sensitivity and Specificity Article Cohort Studies Sepsis 03 medical and health sciences 0302 clinical medicine Enterocolitis Necrotizing Caffeine Intensive Care Units Neonatal 030225 pediatrics Intensive care Electric Impedance medicine Humans Monitoring Physiologic business.industry Respiration digestive oral and skin physiology Infant Newborn Recem nascido Infant Gestational age Respiration Disorders medicine.disease Periodic breathing Pediatrics Perinatology and Child Health Necrotizing enterocolitis Intensive Care Neonatal Breathing Female business Infant Premature 030217 neurology & neurosurgery |
| Zdroj: | Pediatric research |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1038/pr.2016.58 |
| Popis: | Background Periodic breathing (PB) is a normal immature breathing pattern in neonates that, if extreme, may be associated with pathologic conditions. Methods We used our automated PB detection system to analyze all bedside monitor chest impedance data on all infants 50 infant-years’ data). Extreme PB was identified as a 12h period with PB >6 standard deviations above the mean for gestational age (GA) and post-menstrual age (PMA) and >10% time in PB. Results PB increased with GA, with the highest amount in infants 30-33 weeks’ GA at about 2 weeks’ chronologic age. Extreme PB was identified in 76 infants and in 45% was temporally associated with clinical events including infection or necrotizing enterocolitis (NEC), immunizations, or caffeine discontinuation. In 8/28 cases of septicemia and 10/21 cases of NEC there was a >2-fold increase in %PB over baseline in the day prior to diagnosis. Conclusion Infants |
| Databáze: | OpenAIRE |
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