An evidence of brain-heart disorder: mental stress-induced myocardial ischemia regulated by inflammatory cytokines
| Autor: | Meiyan Liu, Dong-Fang He, Wan Xu, Jianyang Liu, Chaitu Dandu, Yingbin Ge, Wanlin Wei, Lijun Zhang |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Myocardial ischemia Myocardial Ischemia Proinflammatory cytokine Coronary artery disease 03 medical and health sciences Heart disorder 0302 clinical medicine Mental stress Internal medicine medicine Humans cardiovascular diseases Aged Aged 80 and over Inflammation business.industry General Medicine Middle Aged medicine.disease 030104 developmental biology Increased risk Neurology Cardiology Cytokines Female Neurology (clinical) Inflammation Mediators business 030217 neurology & neurosurgery Biomarkers Stress Psychological |
| Zdroj: | Neurological research. 42(8) |
| ISSN: | 1743-1328 |
| Popis: | Underlying Coronary Artery Disease (CAD) complicated by Mental Stress-Induced Myocardial Ischemia (MSIMI) has been linked with an increased risk for adverse cardiovascular events and even sudden death. However, the underlying mechanisms of MSIMI remain unknown. In this study, we investigated cytokine levels at baseline inflammation status and during acute inflammatory responses to mental stress in patients with known CAD who presented with MSIMI.77 patients with known CAD were recruited and all underwent echocardiography before and during arithmetic stress task. MSIMI was diagnosed by new or worsening wall motion abnormalities greater than or equal to a 5% reduction of left ventricle ejection fraction. Inflammatory markers were measured both before and immediately after the Mental Stress (MS) by ELISA kits. Repeated measures models were used to report the responses and mixed linear regression models were used to report the differences between MSIMI negative and positive patients.MS induced a significant increase in Stromal Cell-Derived Factor-1α (SDF-1α) and Monocyte Chemoattractant Protein-1 (MCP-1) in all subjects; 20.78% of the patients with known CAD developed MSIMI during the arithmetic task. MSIMI positive patients had significantly lower baseline levels of Interleukin-1β (IL-1β) and Tumor Necrosis Factor-α (TNF-α), but a higher response in levels of SDF-1α than MSIMI negative patients.MS can induce acute inflammatory responses. MSIMI is associated with lower levels of IL-1β and TNF-α at baseline and higher levels of SDF-1α in response to MS. |
| Databáze: | OpenAIRE |
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