A comparison of the genetic and clinical risk factors for arterial hypertension between indigenous and non-indigenous people of the Shoria Mountain Region

Autor: Olga Barbarash, T. A. Mulerova, Michael Voevoda, Evgenya Uchasova, Michael Ogarkov
Rok vydání: 2017
Předmět:
Male
Physiology
Ethnic group
030204 cardiovascular system & hematology
Overweight
Russia
0302 clinical medicine
Risk Factors
Epidemiology
Ethnicity
Prevalence
030212 general & internal medicine
Abdominal obesity
education.field_of_study
General Medicine
Middle Aged
Muscle Spasticity
Obesity
Abdominal
Hypertension
Female
Homocystinuria
medicine.symptom
Clinical risk factor
Adult
medicine.medical_specialty
Adolescent
Genotype
Population
Peptidyl-Dipeptidase A
Indigenous
03 medical and health sciences
Young Adult
Asian People
Receptors
Adrenergic
alpha-2
Glucose Intolerance
Internal Medicine
medicine
Humans
Arterial Pressure
education
Methylenetetrahydrofolate Reductase (NADPH2)
Aged
Polymorphism
Genetic
business.industry
Body Weight
medicine.disease
Obesity
Psychotic Disorders
Physical therapy
business
Demography
Zdroj: Clinical and experimental hypertension (New York, N.Y. : 1993). 40(4)
ISSN: 1525-6006
Popis: This study investigated the non-genetic and genetic risk factors for arterial hypertension (AH) in two ethnic groups living in the Mountain Shoria region: Shors and non-indigenous people.Clinical and epidemiological study of compactly living population in the remote areas of the Mountain Shoria (Orton, Ust-Kabyrza, Sheregesh settlements, Kemerovo region). 1178 residents of these settlements were surveyed with the help of continuous sampling method; the sample consisted of adults (18 years and older).The prevalence of AH was lower in Shors (39.9% vs. 46.1%), mainly due to differences between men from the different groups: 33.2% vs. 45.8%. The percentage of people with AH, overweight, and obesity (including transabdominal obesity) in the different age groups did not differ between ethnicities. We identified statistically significant differences in the prevalence of hypertension according the two ethic groups according to age, body weight, and abdominal obesity. I/D ACE and ADRA2B polymorphisms were associated with AH. In DD ACE and DD ADRA2B carriers, there were fewer hypertensive patients in Shors than in non-indigenous people: 40.6% vs. 58.6% and 38.3% vs. 64.0%, respectively. In DD ACE carriers, more Shors had AH (60.0% vs. 37.1%).Among Shors, the following factors increased AH risk: female sex, age, hypercholesterolemia, hyperbetacholesterinemia, hypertriglyceridemia, obesity (including transabdominal obesity), glucose intolerance, and the DD ACE, CT MTHFR, and AA ADRB1 genotypes; among the non-indigenous population, the main factors were age, hypercholesterolemia, hyperbetacholesterinemia, hypoalfacholesterinemia, hypertriglyceridemia, obesity (including transabdominal obesity), and ID ACE genotype.
Databáze: OpenAIRE
Externí odkaz: