Associations analysis of GSTM1, T1 and P1 Ile105Val polymorphisms with carpal tunnel syndrome
| Autor: | Ozlem Gorukmez, Esra Erkol İnal, Ali Topak, Pınar Eroğlu, Tahsin Yakut, Sebnem Ozemri Sag |
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| Přispěvatelé: | Uludağ Üniversitesi/Tıp Fakültesi//Tıbbi Genetik Anabilim Dalı., Sağ, Şebnem Özemri, Görükmez, Özlem, Topak, Ali, Yakut, Tahsin, HNQ-2791-2023, AAH-8355-2021, AFZ-0764-2022 |
| Rok vydání: | 2014 |
| Předmět: |
0301 basic medicine
Male Type-2 diabetes-mellitus M1 Wrist pain Gastroenterology Severity of Illness Index Acute-leukemia Hand pain 0302 clinical medicine Gene Frequency GSTP1 polymorphisms Genotype Medicine Visual analog scale Glutathione S-Transferase M1 Cytochrome P-450 CYP1A1 Priority journal Glutathione Transferase Allele GSTT1 Boston FSS Gene polymorphisms Valine General Medicine Middle Aged GSTP1 protein human Carpal Tunnel Syndrome Polymerase chain reaction Cervical-cancer risk 030220 oncology & carcinogenesis GSTP1-Ile105Val Female medicine.symptom Restriction fragment length polymorphism Human Adult Glutathione-s-transferase medicine.medical_specialty Visual analogue scale Genotypes Case control study Major clinical study Polymorphism Single Nucleotide Article Boston SSS 03 medical and health sciences Rheumatology Glutathione transferase M1 Internal medicine Genetics Humans Genetic Predisposition to Disease Carpal tunnel syndrome Glutathione S-transferase M1 Alleles Genetic Association Studies Disease duration Genetic association study Genetic polymorphism business.industry Glutathione S-transferase T1 Genetic predisposition Odds ratio medicine.disease DNA isolation Confidence interval Single nucleotide polymorphism nervous system diseases Surgery Oxidative Stress Glutathione transferase T1 030104 developmental biology Glutathione S-Transferase pi Susceptibility Case-Control Studies Glutathione transferase P1 Boston symptom severity scale Genetic association business Reactive oxygen metabolite Controlled study GSTM1 |
| Zdroj: | Clinical rheumatology. 35(5) |
| ISSN: | 1434-9949 |
| Popis: | Oxidative stress was related with carpal tunnel syndrome (CTS). We aimed to clarify the associations between glutathione S-transferase (GST)M1, GSTT1 and GSTP1-Ile105Val polymorphisms and CTS. One hundred-forty patients with CTS and 97 healthy controls were enrolled in this study. Tinel and Phalen signs were noted as positive or negative. Functional and clinical status of patients was evaluated by the Boston Questionnaire. The intensity of hand and/or wrist pain was evaluated on 10 cm visual analog scale (VAS). We applied the polymerase chain reaction (PCR) to determine the polymorphisms of the GSTM1 and GSTT1 and the PCR-restriction fragment length polymorphism method for detecting the GSTP1-Ile105Val polymorphism. The M1 null genotype was significantly higher in patients with CTS compared to healthy controls, and the M1 null genotype seemed to increase the risk of CTS approximately two-fold (P = 0.011; odds ratio (OR) = 1.98; 95 % confidence interval (CI) 1.17-3.36). The M1 null, T1 present combined genotype was significantly higher in patients with CTS compared to healthy controls (P = 0.043); however, it seemed not to increase the risk of CTS (P = 0.14; OR = 0.62; 95 % CI 0.33-1.76). We found significantly higher levels of the VAS, Boston Symptom Severity Scale and Phalen sign in patients with the Ile/Val or the Val/Val genotypes compared to those in patients with the Ile/Ile genotype (P = 0.003, 0.004 and 0.044, respectively). We proposed that genes involved in the protection from oxidative stress may influence the susceptibility, clinical and functional status of CTS. The GSTM1 null genotype may be related with the development of CTS, whereas the Val allele of GSTP1-Ile105Val polymorphism may be associated with worse functional and clinical status in CTS. |
| Databáze: | OpenAIRE |
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