Circadian Regulation by REV-ERBα Mediates Hippocampal E-LTP in a Time-dependent Manner
| Autor: | Somi Kim, Jisu Lee, Ja Eun Choi, Kyungjin Kim, Bong-Kiun Kaang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Circadian clock system Circadian rhythm Short Communication viruses Circadian clock Hippocampus Long-term potentiation Hippocampal formation Biology 03 medical and health sciences Cellular and Molecular Neuroscience 030104 developmental biology Rhythm Nuclear receptor Neuronal plasticity Neuroplasticity Neurology (clinical) Neuroscience |
| Zdroj: | Experimental Neurobiology |
| ISSN: | 2093-8144 1226-2560 |
| DOI: | 10.5607/en.2018.27.5.344 |
| Popis: | Circadian rhythms are driven by circadian oscillators, and these rhythms result in the biological phenomenon of 24-h oscillations. Previous studies suggest that learning and memory are affected by circadian rhythms. One of the genes responsible for generating the circadian rhythm is Rev-erbα. The REV-ERBα protein is a nuclear receptor that acts as a transcriptional repressor, and is a core component of the circadian clock. However, the role of REV-ERBα in neurophysiological processes in the hippocampus has not been characterized yet. In this study, we examined the time-dependent role of REV-ERBα in hippocampal synaptic plasticity using Rev-erbα KO mice. The KO mice lacking REV-ERBα displayed abnormal NMDAR-dependent synaptic potentiation (E-LTP) at CT12~CT14 (subjective night) when compared to their wild-type littermates. However, Rev-erbα KO mice exhibited normal E-LTP at CT0~CT2 (subjective day). We also found that the Rev-erbα KO mice had intact late LTP (L-LTP) at both subjective day and night. Taken together, these results provide evidence that REV-ERBα is critical for hippocampal E-LTP during the dark period. Graphical Abstract |
| Databáze: | OpenAIRE |
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