Association between MRI-derived hepatic fat fraction and blood pressure in participants without history of cardiovascular disease
| Autor: | Holger Hetterich, Susanne Rospleszcz, Christa Meisinger, Wolfgang Lieb, Margit Heier, Sigrid Auweter, Roberto Lorbeer, Annette Peters, Christian Bayerl, Fabian Bamberg |
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| Jazyk: | němčina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Percentile medicine.medical_specialty Physiology Population Blood Pressure 030204 cardiovascular system & hematology Logistic regression Hepatic Fat Fraction Hypertension Mri 03 medical and health sciences 0302 clinical medicine Internal medicine Internal Medicine medicine Humans education Stroke Aged Subclinical infection education.field_of_study business.industry Fatty liver Odds ratio Middle Aged medicine.disease Magnetic Resonance Imaging Fatty Liver Blood pressure Liver Cardiology Female 030211 gastroenterology & hepatology Cardiology and Cardiovascular Medicine business |
| Zdroj: | J. Hypertens. 35, 737-744 (2017) |
| Popis: | OBJECTIVES: We assessed whether liver fat content, as determined by MRI, correlates with blood pressure (BP), a major vascular risk factor, in individuals from the general population without history of stroke and coronary or peripheral artery disease. METHODS: Cross-sectional data from 384 participants (161 women; aged 39-73 years) of a MRI substudy of the KORA FF4 survey were used. Hepatic fat fraction (HFF) was measured in the left and right lobe of the liver using single voxel multiecho H-spectroscopy and at the level of the portal vein using a multiecho Dixon-sequence. Associations of HFF with SBP and DBP as well as hypertension were assessed by right censored normal regression (accounting for antihypertensive treatment) and by logistic regression, respectively. RESULTS: High levels of HFF measured on the level of the portal vein (90th percentile, 21.8%), compared with low HFF levels (10th percentile, 1.7%), were associated with higher SBP (131 vs. 122 mmHg; overall P = 0.001), higher DBP (82 vs. 76 mmHg, P |
| Databáze: | OpenAIRE |
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