Clinical Utility of Urinaryβ2-Microglobulin in Detection of Early Nephropathy in African Diabetes Mellitus Patients
| Autor: | A. S. Obot, Effiong Ekong Akpan, Emmanuel E Effa, Kadiri S, Udeme E. Ekrikpo |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Article Subject Urinary system 030232 urology & nephrology Physical examination lcsh:RC870-923 Gastroenterology Nephropathy Diabetic nephropathy 03 medical and health sciences 0302 clinical medicine Tubulopathy Internal medicine Diabetes mellitus medicine Medical history 030212 general & internal medicine medicine.diagnostic_test business.industry lcsh:Diseases of the genitourinary system. Urology medicine.disease Endocrinology Nephrology Microalbuminuria business Research Article |
| Zdroj: | International Journal of Nephrology, Vol 2017 (2017) International Journal of Nephrology |
| ISSN: | 2090-2158 2090-214X |
| Popis: | Background. Studies have indicated that diabetic tubulopathy may occur earlier than glomerulopathy, therefore providing a potential avenue for earlier diagnosis of diabetic nephropathy. Urinary beta-2-microglobulin (β2m) was investigated in this study as a potential biomarker in the detection of early nephropathy in type 2 diabetics.Methods. One hundred and two diabetic subjects and 103 controls that met the inclusion criteria had data (sociodemographic, medical history, physical examination, and laboratory) collected. Urinaryβ2m levels and urinary albumin concentration (UAC) were determined.Results. Elevated urinaryβ2m was more frequent among the diabetics (52%, 95% CI: 42.1–61.8%) than among the controls (32%, 95% CI: 22.9–41.2%). The frequency of microalbuminuria was higher in the diabetics (35.3%, 95% CI: 25.9–44.7%) than in the controls (15.5%, 95% CI: 8.4–22.6%). There was a positive correlation between urinaryβ2m and UAC (rho = 0.38,p<0.001). Multivariate analysis showed BMI (OR: 1.23, 95% CI: 1.05–1.45), eGFR (OR: 0.97, 95% CI: 0.94–0.99), and presence of microalbuminuria (OR: 3.94, 95% CI: 1.32–11.77) as independent predictors of elevated urinary beta-2-microglobulin among the diabetics.Conclusion. Urinaryβ2m may be useful, either as a single test or as a component of a panel of tests, in the early detection of diabetic nephropathy. |
| Databáze: | OpenAIRE |
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