Levalbuterol compared with racemic albuterol in the treatment of acute asthma: results of a pilot study
| Autor: | Louis Vaickus, Rachel L DiSantostefano, James M. Roach, Richard M. Nowak, Charles L. Emerman, Kendyl Schaefer |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.drug_class Pilot Projects Pharmacology Forced Expiratory Volume Bronchodilator Intensive care Bronchodilation Levalbuterol Humans Medicine Albuterol Prospective Studies Asthma Analysis of Variance business.industry Stereoisomerism General Medicine medicine.disease Bronchodilator Agents respiratory tract diseases Treatment Outcome Tolerability Anesthesia Acute Disease Emergency Medicine Salbutamol Female Bronchoconstriction medicine.symptom business medicine.drug |
| Zdroj: | The American Journal of Emergency Medicine. 22:29-36 |
| ISSN: | 0735-6757 |
| DOI: | 10.1016/j.ajem.2003.11.001 |
| Popis: | This was a prospective, open-label, nonrandomized pilot study to evaluate efficacy and tolerability of levalbuterol (LEV) in acute asthma. Asthmatics (forced expiratory volume in 1 second [FEV1], 20-55% predicted) were sequentially enrolled into cohorts of 12 to 14 and received 0.63, 1.25, 2.5, 3.75, or 5.0 mg LEV or 2.5 or 5.0 mg racemic albuterol (RAC) every 20 minutes x 3. After the first dose, FEV1 changes were 56% (0.6 L) for 1.25 mg LEV and 6% (0.07 L) and 14% (0.21 L) for 2.5 and 5 mg RAC respectively. After three doses, FEV1 changes were 74% (0.9 L), 39% (0.5 L), and 37% (0.6 L) for 1.25 mg, LEV 2.5 mg, RAC and 0.63 mg LEV respectively. LEV doses greater than 1.25 mg did not further improve bronchodilation. Baseline plasma (S)-albuterol levels were negatively correlated with baseline FEV1 (R = - 0.3, P = .004) and percent change in FEV1 (R = -0.3, P = .006). LEV at a dose of 1.25 mg produced effective bronchodilation that was greater than both RAC doses. The negative correlation between (S)-albuterol levels and FEV1 could suggest a deleterious effect of (S)-albuterol. Larger comparative studies are warranted. |
| Databáze: | OpenAIRE |
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