The Molecular Identification and Antifungal Susceptibilities of Aspergillus Species Causing Otomycosis in Tochigi, Japan
| Autor: | Hideyo Yamaguchi, Hitoshi Kamewada, Seiichi Shinden, Shigehiro Hagiwara, Takashi Tamura, Kazuo Satoh, Koichi Makimura, Masayasu Nakano |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Azoles Male 0301 basic medicine Antifungal Agents Veterinary (miscellaneous) Luliconazole 030106 microbiology Otomycosis Microbial Sensitivity Tests Ravuconazole Applied Microbiology and Biotechnology Microbiology 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Japan Sensu Tubulin parasitic diseases medicine Aspergillosis Humans skin and connective tissue diseases Efinaconazole Aged Aged 80 and over chemistry.chemical_classification Aspergillus biology Incidence Aspergillus niger Middle Aged bacterial infections and mycoses biology.organism_classification medicine.disease chemistry Azole Female Agronomy and Crop Science geographic locations medicine.drug |
| Zdroj: | Mycopathologia. 184:13-21 |
| ISSN: | 1573-0832 0301-486X |
| DOI: | 10.1007/s11046-018-0299-9 |
| Popis: | Aspergillus species are the most common pathogenic fungi involved in otomycosis, an infection of the outer ear canal. In this study, we examined the incidence of Aspergillus infections and the antifungal susceptibilities of 30 Aspergillus species isolates from patients with otomycosis who visited Saiseikai Utsunomiya Hospital between August 2013 and July 2016. Based on the morphological test results, the strains were identified as Aspergillus niger sensu lato (20 strains), A. terreus sensu lato (7 strains), and A. fumigatus sensu lato (3 strains). In contrast, the molecular identifications based on analyzing the isolates' partial β-tubulin gene sequences revealed them to be A. niger sensu stricto (12 strains), A. tubingensis (8 strains), A. terreus sensu stricto (7 strains), and A. fumigatus sensu stricto (3 strains). The antifungal susceptibility test results indicated that strains of A. tubingensis and A. niger sensu stricto displayed lower susceptibilities to ravuconazole, compared with the other isolates. The Aspergillus strains from this study showed low minimum inhibitory concentrations toward the azole-based drugs efinaconazole, lanoconazole, and luliconazole. Therefore, these topical therapeutic agents may be effective for the treatment of otomycosis. |
| Databáze: | OpenAIRE |
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