The tetraspanin TSP3 of Neurospora crassa is a vacuolar membrane protein and shares characteristics with IDI proteins
| Autor: | Daniela Heine, Stefanie Pöggeler, Leila Rachid, Marcel R. Schumann, Linda Petereit, Diana Patzelt, Antonia Werner, André Fleißner, Ulrike Brandt |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Physiology Tetraspanins 030106 microbiology Mutant Vacuole Neurospora crassa Fungal Proteins 03 medical and health sciences Tetraspanin Organelle Genetics Molecular Biology Ecology Evolution Behavior and Systematics Fungal protein biology fungi Autophagy Membrane Proteins Cell Biology General Medicine biology.organism_classification Cell biology Membrane protein Vacuoles |
| Zdroj: | Mycologia. 108(3) |
| ISSN: | 0027-5514 |
| Popis: | The fungal vacuole is an organelle, which adopts pleiotropic morphologies and functions. In aging and starving hyphae it is the compartment of degradation and recycling of cellular constituents. Here we identified TSP3, one of three tetraspanins present in the filamentous ascomycete fungus Neurospora crassa, as a vacuolar membrane protein. The protein is detected only in aging and starving cultures and under other conditions, which induce autophagy, such as vegetative incompatibility or the presence of the macrolide antibiotic rapamycin. Mutant analysis revealed that TSP3 is dispensable for growth and development of the fungus under laboratory conditions. Together these findings indicate that tsp3 shares characteristics with idi (induced during incompatibility) genes and might promote vacuolar functions related to autophagy. |
| Databáze: | OpenAIRE |
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