The response of brown adipose tissue mitochondrial glycerolphosphate acyltransferase to cold-exposure in hypothyroidism, after adrenalectomy and after treatment with cycloheximide
| Autor: | E.David Saggerson, John R.D. Mitchell |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Acclimatization medicine.medical_treatment Cycloheximide Mitochondrion Biology Hyperthyroidism Biochemistry Rats Sprague-Dawley chemistry.chemical_compound Adipose Tissue Brown Hypothyroidism Internal medicine Adrenal Glands Brown adipose tissue medicine Animals Triiodothyronine Adrenalectomy Mitochondria Rats Cold Temperature medicine.anatomical_structure Endocrinology chemistry Glycerol-3-Phosphate O-Acyltransferase Glycerophosphate Acyltransferase After treatment |
| Zdroj: | International Journal of Biochemistry. 26:67-72 |
| ISSN: | 0020-711X |
| DOI: | 10.1016/0020-711x(94)90197-x |
| Popis: | 1. Exposure to cold has previously been shown to considerably increase the activity of the mitochondrial form of glycerolphosphate acyltransferase (GPAT) in brown adipose tissue (A. C. Darnley, C. A. Carpenter and E. D Saggerson, Biochem. J. 253, 351-355, 1988; J. R. D. Mitchell and E. D. Saggerson. Biochem. J. 277, 665-669, 1991). 2. Both adrenalectomy and chemically-induced hypothyroidism increased mitochondrial GPAT activity in rats maintained at 21 degrees C. This increase was similar to that caused by exposing rats to the cold (4 degrees C) for three days. Whereas exposure of hypothyroid rats to cold (4 degrees C) resulted in a further increase in GPAT activity, no further increase in activity was observed after exposure of adrenalectomized rats to the cold. 3. Administration of triiodothyronine (T3) to rats maintained at 21 degrees C had no effect on mitochondrial GPAT activity. 4. Prior treatment with cycloheximide abolished 60-70% of the increase in GPAT activity caused by cold-exposure. |
| Databáze: | OpenAIRE |
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