Estimating distances from the centromere by means of benign ovarian teratomas in man
| Autor: | Frederick Hecht, Jurg Ott, Everett W. Lovrien, David Linder, Barbara Kaiser McCAW |
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| Rok vydání: | 1976 |
| Předmět: |
Heterozygote
endocrine system endocrine system diseases Genetic Linkage Biology urologic and male genital diseases Models Biological Meiosis Centromere Genetics medicine Humans Ovarian Teratoma neoplasms Gene Genetics (clinical) Ovarian Neoplasms Teratoma Fungal genetics Chromosome Mapping medicine.disease female genital diseases and pregnancy complications medicine.anatomical_structure Female Germ cell |
| Zdroj: | Annals of Human Genetics. 40:191-196 |
| ISSN: | 1469-1809 0003-4800 |
| DOI: | 10.1111/j.1469-1809.1976.tb00179.x |
| Popis: | Under the assumption that benign ovarian teratomas in man arise parthenogenically from a germ cell by suppression of the second meiotic division, the distance of a gene from its centromere can be estimated from the observed proportion of heterozygous teratomas collected from heterozygous hosts. The frequency of heterozygous teratomas of heterozygous hosts is equivalent to the frequency of second division segregation at the gene locus which has been used for centromere-related mapping in fungal genetics for more than 40 years. Mapping functions useful for teratoma-based mapping in man are presented. |
| Databáze: | OpenAIRE |
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