Fully Implanted Prostheses for Musculoskeletal Limb Reconstruction After Amputation: An In Vivo Feasibility Study
| Autor: | Dustin L. Crouch, Stacy Stephenson, Cheryl B. Greenacre, Remi M. Grzeskowiak, Caleb Stubbs, Patrick T. Hall, Bryce J. Burton, Samantha Z. Bratcher, David E. Anderson, Rebecca E. Rifkin |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Medullary cavity medicine.medical_treatment 0206 medical engineering Biomedical Engineering Artificial Limbs 02 engineering and technology Dehiscence Prosthesis Design Amputation Surgical Article Osseointegration Prosthesis Implantation Weight-Bearing medicine Animals Muscle Skeletal Tibia business.industry Plastic Surgery Procedures 020601 biomedical engineering Hindlimb Surgery Amputation Orthopedic surgery Feasibility Studies Rabbits business Surgical incision Residual limb Bandage |
| Zdroj: | Ann Biomed Eng |
| ISSN: | 1573-9686 0090-6964 |
| DOI: | 10.1007/s10439-020-02645-3 |
| Popis: | Previous prostheses for replacing a missing limb following amputation must be worn externally on the body. This limits the extent to which prostheses could physically interface with biological tissues, such as muscles, to enhance functional recovery. The objectives of our study were to (1) test the feasibility of implanting a limb prosthesis, or endoprosthesis, entirely within living skin at the distal end of a residual limb, and (2) identify effective surgical and post-surgical care approaches for implanting endoprostheses in a rabbit model of hindlimb amputation. We iteratively designed, fabricated, and implanted unjointed endoprosthesis prototypes in six New Zealand White rabbits following amputation. In the first three rabbits, the skin failed to heal due to ishemia and dehiscence along the sutured incision. The skin of the final three subsequent rabbits successfully healed over the endoprotheses. Factors that contributed to successful outcomes included modifying the surgical incision to preserve vasculature; increasing the radii size on the endoprostheses to reduce skin stress; collecting radiographs pre-surgery to match the bone pin size to the medullary canal size; and ensuring post-operative bandage integrity. These results will support future work to test jointed endoprostheses that can be attached to muscles. |
| Databáze: | OpenAIRE |
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