Comparison of Unsatisfactory Samples from Conventional Smear versus Liquid-Based Cytology in Uterine Cervical Cancer Screening Test
| Autor: | Jong Jae Jung, Sun Hee Sung, Hoiseon Jeong, Sung-Chul Lim, Eun Jung Park, Sung Nam Kim, Eun Kyung Kim, J.M. Lee, So-Young Jin, Sung Ran Hong, Seoung-Wan Chae, Sook Tai Ha, Hye Kyoung Yoon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Histology Uterine cervical cancer Screening test Papanicolaou stain Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Cytology lcsh:Pathology medicine Cervical cytology Liquid-based cytology 030212 general & internal medicine Pap test Unsatisfactory medicine.diagnostic_test Obstetrics business.industry Papanicolaou Test Papanicolaou test Conventional smear 030220 oncology & carcinogenesis Original Article business lcsh:RB1-214 |
| Zdroj: | Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine, Vol 51, Iss 3, Pp 314-319 (2017) |
| ISSN: | 2383-7845 2383-7837 |
| Popis: | Background Cervical cytology for uterine cervical cancer screening has transitioned from conventional smear (CS) to liquid-based cytology (LBC), which has many advantages. The aim of this study was to compare the proportion of unsatisfactory specimens from CS versus LBC at multiple institutions including general hospitals and commercial laboratories. Methods Each participating institution provided a minimum of 500 Papanicolaou (Pap) test results for analysis. Pap tests were classified according to the participating institution (commercial laboratory or general hospital) and the processing method (CS, ThinPrep, SurePath, or CellPrep). The causes of unsatisfactory results were classified as technical problems, scant cellularity, or complete obscuring factors. Results A total of 38,956 Pap test results from eight general hospitals and three commercial laboratories were analyzed. The mean unsatisfactory rate of LBC was significantly lower than that of CS (1.26% and 3.31%, p = .018). In the LBC method, samples from general hospitals had lower unsatisfactory rates than those from commercial laboratories (0.65% vs 2.89%, p = .006). The reasons for unsatisfactory results were heterogeneous in CS. On the other hand, 66.2% of unsatisfactory results in LBC were due to the scant cellularity. Conclusions Unsatisfactory rate of cervical cancer screening test results varies according to the institution and the processing method. LBC has a significantly lower unsatisfactory rate than CS. |
| Databáze: | OpenAIRE |
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