Seronegative Neuromyelitis Optica Spectrum Disorder: An Unusual Presentation of Acute Brainstem Syndrome
| Autor: | Mashael Omar Alkhateeb, Zahra Haider Alshurafa |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Vomiting Serology otorhinolaryngologic diseases Laryngopharyngeal Reflux medicine Humans Spectrum disorder Aquaporin 4 Medulla Oblongata Neuromyelitis optica medicine.diagnostic_test business.industry Neuromyelitis Optica Magnetic resonance imaging Articles General Medicine Dysphonia Spinal cord medicine.disease Magnetic Resonance Imaging Dermatology Dysphagia medicine.anatomical_structure Female Brainstem medicine.symptom Deglutition Disorders business Brain Stem |
| Zdroj: | The American Journal of Case Reports |
| ISSN: | 1941-5923 |
| DOI: | 10.12659/ajcr.922590 |
| Popis: | Patient: Female, 27-year-old Final Diagnosis: Acute brainstem syndrome • seronegative neuromyelitis optical spectrum disorder Symptoms: Dysphagia • dysphonia • hoarseness • vomiting Medication:— Clinical Procedure: — Specialty: — Objective: Unusual clinical course Background: Neuromyelitis optica (NMO) is an autoimmune, demyelinating, inflammatory disorder affecting the central nervous system, mostly targeting optic nerves and the spinal cord. NMO spectrum disorder (NMOSD) is a newly revised nomenclature in which new diagnostic criteria have been developed, including serological testing of serum aquaporin-4 immunoglobulin G (AQP4-IgG) antibodies. Results of a negative antibody will group the patient in a seronegative subgroup. Case Report: We describe the case of a 27-year-old female who presented to our hospital with new onset of sudden unexplained vomiting, dysphagia, dysphonia, and food regurgitation. Extensive investigations were done and brain magnetic resonance imaging (MRI) showed a small nonspecific area of signal abnormality in the right dorsal medulla. Aquaporin-4 antibodies were negative, and the patient was diagnosed with seronegative NMOSD with acute brainstem syndrome after meeting the diagnostic criteria. The patient’s condition improved after steroids administration. Conclusions: We report an unusual presentation of seronegative NMOSD presenting with acute brainstem syndrome. |
| Databáze: | OpenAIRE |
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