The role of vitamin C in stress-related disorders
| Autor: | Ana Lúcia S. Rodrigues, Mauricio P. Cunha, Bettina Moritz, Alcir Luiz Dafre, Ariana Ern Schmitz |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Vitamin medicine.drug_class Endocrinology Diabetes and Metabolism Clinical Biochemistry Ascorbic Acid Pharmacology Anxiety Biochemistry Neuroprotection Anxiolytic Antioxidants 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Medicine Animals Humans Molecular Biology Depressive Disorder Nutrition and Dietetics Vitamin C business.industry Depression Stress-related disorders Ascorbic acid Anxiety Disorders 030104 developmental biology Neuroprotective Agents chemistry Antidepressant medicine.symptom business 030217 neurology & neurosurgery Stress Psychological |
| Zdroj: | The Journal of nutritional biochemistry. 85 |
| ISSN: | 1873-4847 |
| Popis: | Stress-related disorders, such as depression and anxiety, present marked deficits in behavioral and cognitive functions related to reward. These are highly prevalent disabling conditions with high social and economic costs. Furthermore, a significant percentage of affected individuals cannot benefit from clinical intervention, opening space for new treatments. Although the literature data have reported limited and variable results regarding oxidative stress-related endpoints in stress-related disorders, the possible neuroprotective effect of antioxidant compounds, such as ascorbic acid (vitamin C), emerges as a possible therapy strategy for psychiatric diseases. Here, we briefly present background information on biological activity of ascorbic acid, particularly functions related to the CNS homeostasis. Additionaly, we reviewed the available information on the role of ascorbic acid in stress-related diseases, focusing on supplementation and depletion studies. The vitamin C deficiency is widely associated to stress-related diseases. Although the efficacy of this vitamin in anxiety spectrum disorders is less stablished, several studies showed that ascorbic acid supplementation produces antidepressant effect and improves mood. Interestingly, the modulation of monoaminergic and glutamatergic neurotransmitter systems is postulated as pivotal target for the antidepressant and anxiolytic effects of this vitamin. Given that ascorbic acid supplementation produces fast therapeutic response with low toxicity and high tolerance, it can be considered as a putative candidate for the treatment of mood and anxiety disorders, especially those that are refractory to current treatments. Herein, the literature was reviewed considering the potential use of ascorbic acid as an adjuvant in the treatment of anxiety and depression. |
| Databáze: | OpenAIRE |
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