The regulatory strategies of c-myc and c-fos proto-oncogenes share some common mechanisms
Autor: | mechti, nadir, Blanchard, Jean-Marie, Piechaczyk, Marc, Fort, Philippe, Bonnieu, Anne, Mechti, Nadia, Rech, Jocelyne, Cuny, Marguerite, Lebleu, Bernard, Jeanteur, Philippe |
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Přispěvatelé: | Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre de recherches de biochimie macromoléculaire (CRBM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-IFR122-Centre National de la Recherche Scientifique (CNRS), Dynamique Musculaire et Métabolisme (DMEM), Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM), Dynamique des interactions membranaires normales et pathologiques (DIMNP), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS) |
Jazyk: | angličtina |
Rok vydání: | 1988 |
Předmět: |
MESH: RNA Processing
Post-Transcriptional Transcription Genetic [SDV]Life Sciences [q-bio] [SDV.CAN]Life Sciences [q-bio]/Cancer [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC] Biology [SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics Phylogenetics and taxonomy Biochemistry 03 medical and health sciences Exon 0302 clinical medicine Transcription (biology) Proto-Oncogenes Mouse Plasma Cell Transcriptional regulation Animals Humans MESH: Animals RNA Messenger RNA Processing Post-Transcriptional Gene 030304 developmental biology MESH: RNA Messenger 0303 health sciences C-fos Genes MESH: Humans Oncogene MESH: Transcription Genetic RNA [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biology General Medicine Molecular biology MESH: Gene Expression Regulation [SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis Gene Expression Regulation 030220 oncology & carcinogenesis MESH: Proto-Oncogenes |
Zdroj: | Biochimie Biochimie, Elsevier, 1988, 70 (7), pp.877-884. ⟨10.1016/0300-9084(88)90228-3⟩ Biochimie, Elsevier, 1988, 70 (7), pp.877-84. ⟨10.1016/0300-9084(88)90228-3⟩ |
ISSN: | 0300-9084 |
DOI: | 10.1016/0300-9084(88)90228-3⟩ |
Popis: | International audience; There is evidence for both transcriptional and post-transcriptional levels of regulation of c-fos and c-myc proto-oncogenes. Transcription of both genes can be regulated at the level of initiation. However, it was recently shown in various situations for c-myc, and in one case for c-fos, that these genes can also be down-regulated by a block to elongation of nascent RNA chains. Both c-myc and c-fos mRNAs are known to be extremely unstable (half-lives around 10-15 min) and c-myc RNA turnover has been shown to be modulated under various physiological situations. Atypical c-myc RNAs found in certain mouse plasma cell tumors (MPCs) and Burkitt, lymphomas (BLs) are significantly and sometimes dramatically more stable than their normal counterparts. In this review we report that: i) transcriptional control elements reside in murine c-myc and c-fos first exons. Daudi cells provide an example of c-myc activation via removal of this block to elongation; ii) elements necessary for the rapid degradation of c-fos and c-myc RNAs reside in their 3' non-coding regions; iii) these destabilizing elements can be counteracted by atypical 5' sequences found in abnormal c-myc transcripts from BLs and mouse plasmocytomas. |
Databáze: | OpenAIRE |
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