Protein structure prediction using mutually orthogonal Latin squares and a genetic algorithm

Autor: N. Gautham, V. Kanagasabai, Jothi Arunachalam
Rok vydání: 2006
Předmět:
Zdroj: Biochemical and biophysical research communications. 342(2)
ISSN: 0006-291X
Popis: We combine a new, extremely fast technique to generate a library of low energy structures of an oligopeptide (by using mutually orthogonal Latin squares to sample its conformational space) with a genetic algorithm to predict protein structures. The protein sequence is divided into oligopeptides, and a structure library is generated for each. These libraries are used in a newly defined mutation operator that, together with variation, crossover, and diversity operators, is used in a modified genetic algorithm to make the prediction. Application to five small proteins has yielded near native structures.
Databáze: OpenAIRE