Incidental adenocarcinoma in patients undergoing surgery for stricturing Crohn's disease
| Autor: | Stanislaus Argeny, Svenja Maschke, Anton Stift, Stefan Riss, Ivan Kristo, Praminthra Chitsabesan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Gastrointestinal Colorectal cancer Rectum Constriction Pathologic Adenocarcinoma Malignancy Descending colon 03 medical and health sciences 0302 clinical medicine Crohn Disease Medicine Retrospective Cohort Study Incidental Humans Stage IIIC Stage (cooking) Colorectal Colectomy Cancer Aged Neoplasm Staging Retrospective Studies Stenosis Incidental Findings business.industry Gastroenterology General Medicine Middle Aged medicine.disease Prognosis Surgery Crohn's disease medicine.anatomical_structure 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Female business Colorectal Neoplasms |
| Zdroj: | World Journal of Gastroenterology |
| ISSN: | 2219-2840 1007-9327 |
| Popis: | AIM To evaluate frequency and clinical course of incidental adenocarcinoma in patients with stricturing Crohn's disease (CD). METHODS In this study, consecutive patients, who were operated on for stricturing CD between 1997-2012, were included at an academic tertiary referral center. Demographic data and clinical course were obtained by an institutional database and individual chart review. Besides baseline characteristics, intraoperative findings and CD related history were also recorded. Colorectal cancer was classified and staged according to the Union for International Cancer Control (UICC). RESULTS During the study period 484 patients underwent resections due to stricturing CD. Incidental adenocarcinoma was histologically confirmed in 6 (1.2%) patients (4 males, 2 females). Patients diagnosed with colorectal cancer had a median age of 43 (27-66) years and a median history of CD of 16 (7-36) years. Malignant lesions were found in the rectum (n = 4, 66.7%), descending colon (n = 1, 16.7%) and ileocolon (n = 1, 16.7%). According to the UICC classification two patients were stages as I (33.3%), whereas the other patients were classified as stage IIA (16.7%), stage IIIB (16.7%), stage IIIC (16.7%) and stage IV (16.7%), respectively. After a median follow-up of 2 (0.03-8) years only 1 patient is still alive. CONCLUSION The frequency of incidental colorectal cancer in patients, who undergo surgery for stenotic CD, is low but associated with poor prognosis. However, surgeons need to be aware about the possibility of malignancy in stricturing CD, especially if localized in the rectum. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|