A role for NGF and its receptors TrKA and p75NTR in the progression of COPD
| Autor: | Lucio Casali, Roberto Tiribuzi, Alessandra Pistilli, Mario Rende, Anna Maria Stabile, Lucia Crispoltoni, Claudia Montagnoli |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine neurotrophin receptors Clinical Biochemistry smoking habit Enzyme-Linked Immunosorbent Assay Nerve Tissue Proteins Inflammation Receptors Nerve Growth Factor neurotrophins Severity of Illness Index Biochemistry Peripheral blood mononuclear cell Pulmonary Disease Chronic Obstructive 03 medical and health sciences Nerve Growth Factor medicine Humans Receptor trkA Receptor Molecular Biology Aged COPD biology business.industry airways diseases Monocyte Middle Aged medicine.disease cytokines 030104 developmental biology medicine.anatomical_structure Nerve growth factor Immunology Disease Progression biology.protein Female Tumor necrosis factor alpha medicine.symptom business Neurotrophin |
| Zdroj: | Biological Chemistry. 397:157-163 |
| ISSN: | 1437-4315 1431-6730 |
| Popis: | Nerve growth factor and its receptors, TrkA and p75NTR, are involved in inflammation and airways diseases, but their role in chronic obstructive pulmonary disease is still unclear and not well investigated. our data indicate the stage dependent variation of nerve growth factor and its receptors in chronic obstructive pulmonary disease progression. In fact, for the first time, this study evaluates the presence of nerve growth factor and its receptors in serum and in peripheral blood mononuclear cells of patients with different stages of chronic obstructive pulmonary disease compared to healthy subjects, non-smoker and current smoker. Serum monocyte chemoattractant protein-1, tumor necrosis factor-α, interleukin-10 and forced expiratory volume in 1 s were also analyzed. Compared to healthy subjects, chronic obstructive pulmonary disease patients presented a staging-dependent increase in serum nerve growth factor, negatively correlated to forced expiratory volume in 1 s and positively to monocyte chemoattractant Protein-1. The percentage of p75NTR+ peripheral blood mononuclear cells increased in early stages of chronic obstructive pulmonary disease (I–II), while TrKA+ peripheral blood mononuclear cells increased in late stages (III–IV). Our data demonstrate the involvement and modulation of nerve growth factor and its receptors in chronic obstructive pulmonary disease and in its staging. |
| Databáze: | OpenAIRE |
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