Synthesis and Antioxidant Properties of NovelN-H andN-Substituted Propanamide Derivatives
| Autor: | Zuhal Kiliç, Ahmet Oguz Ada, Tülay Çoban, Sureyya Olgen |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Indoles Antioxidant Stereochemistry medicine.medical_treatment Pharmaceutical Science In Vitro Techniques medicine.disease_cause Antioxidants Superoxide dismutase Lipid peroxidation Structure-Activity Relationship chemistry.chemical_compound Drug Discovery medicine Animals Enzyme Inhibitors Rats Wistar Indole test Molecular Structure biology Medical treatment Superoxide Dismutase Superoxide Amides Propanamide Rats chemistry Microsomes Liver biology.protein Lipid Peroxidation Oxidative stress |
| Zdroj: | Archiv der Pharmazie. 340:140-146 |
| ISSN: | 1521-4184 0365-6233 |
| Popis: | The interest in the application of antioxidants for medical treatment has been growing recently. A lot of evidence has proven the link between the development of human diseases and oxidative stress. Indole derivatives were found to be very effective in protecting against oxidative stress. Recent exciting findings have demonstrated that several indole derivatives (IDs) are strong inhibitors of superoxide anion (SOD) and lipid peroxidation (LP). In this study, a series of novel N-H and N-substituted indole-3-propanamide derivatives (I3PADs) have been prepared and their efficiencies were investigated towards SOD and LP. Among the synthesized I3PADs, compounds 5 and 7-12 significantly inhibited O 2 .- in the range of 94-100%. In addition, N-H I3PADs showed a stronger inhibitory effect (compounds 1-5, 56-83%) on lipid peroxidation levels than SOD. |
| Databáze: | OpenAIRE |
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