The vascular basement membrane in the healthy and pathological brain
| Autor: | Lisa Juul Routhe, Maj Schneider Thomsen, Torben Moos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Proteases Review Article Matrix (biology) Blood–brain barrier Basement Membrane 03 medical and health sciences Downregulation and upregulation Laminin medicine Journal Article Humans Basement membrane Brain Diseases biology Chemistry Proteolytic enzymes Brain Cell biology 030104 developmental biology medicine.anatomical_structure Neurology Blood-Brain Barrier biology.protein Endothelium Vascular Neurology (clinical) Cardiology and Cardiovascular Medicine Astrocyte |
| Zdroj: | Thomsen, M S, Routhe, L J & Moos, T 2017, ' The vascular basement membrane in the healthy and pathological brain ', Journal of Cerebral Blood Flow and Metabolism, vol. 37, no. 10, pp. 3300-3317 . https://doi.org/10.1177/0271678X17722436 |
| Popis: | The vascular basement membrane contributes to the integrity of the blood-brain barrier (BBB), which is formed by brain capillary endothelial cells (BCECs). The BCECs receive support from pericytes embedded in the vascular basement membrane and from astrocyte endfeet. The vascular basement membrane forms a three-dimensional protein network predominantly composed of laminin, collagen IV, nidogen, and heparan sulfate proteoglycans that mutually support interactions between BCECs, pericytes, and astrocytes. Major changes in the molecular composition of the vascular basement membrane are observed in acute and chronic neuropathological settings. In the present review, we cover the significance of the vascular basement membrane in the healthy and pathological brain. In stroke, loss of BBB integrity is accompanied by upregulation of proteolytic enzymes and degradation of vascular basement membrane proteins. There is yet no causal relationship between expression or activity of matrix proteases and the degradation of vascular matrix proteins in vivo. In Alzheimer’s disease, changes in the vascular basement membrane include accumulation of Aβ, composite changes, and thickening. The physical properties of the vascular basement membrane carry the potential of obstructing drug delivery to the brain, e.g. thickening of the basement membrane can affect drug delivery to the brain, especially the delivery of nanoparticles. |
| Databáze: | OpenAIRE |
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