First line therapy with paclitaxel (Taxol®) and pegylated liposomal doxorubicin (Caelyx®) in patients with metastatic breast cancer: a multicentre phase II study
| Autor: | C. Slabber, D. A. Vorobiof, Martin Chasen, C. Mohammed, Bernardo Leon Rapoport, G. McMichael, R. Eek |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Lung Neoplasms Paclitaxel medicine.medical_treatment Phases of clinical research Bone Neoplasms Breast Neoplasms Soft Tissue Neoplasms Disease-Free Survival South Africa chemistry.chemical_compound Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Neoplasm Metastasis Aged Chemotherapy business.industry Liver Neoplasms Cancer Combination chemotherapy General Medicine Middle Aged medicine.disease Survival Analysis Metastatic breast cancer Treatment Outcome chemistry Doxorubicin Liposomes Toxicity Female Surgery business Febrile neutropenia |
| Zdroj: | The Breast. 13:219-226 |
| ISSN: | 0960-9776 |
| DOI: | 10.1016/j.breast.2004.01.006 |
| Popis: | The aim of this multicentric phase II study was to investigate the efficacy and toxicity of a combination of chemotherapy containing paclitaxel (Taxol) and a novel compound, a liposomal encapsulated doxorubicin (Caelyx), as first line therapy for patients with metastatic breast cancer. Thirty-four patients with advanced breast cancer were treated with a combination of paclitaxel 175 mg/m2 and liposomal doxorubicin 30 mg/m2, every 3 weeks. The combination chemotherapy was effective in 73% of the patients (ITT) (95% CI 55-86%) (7 complete and 18 partial responses). Grade 3/4 toxicities were documented in a small number of patients. Two toxic deaths (6%) were documented, one a hepatorenal failure and another a febrile neutropenia. One patient experienced pulmonary embolism but continued on treatment after appropriate therapy. The combination of paclitaxel and liposomal encapsulated doxorubicin induces a high and durable response rate with a moderate toxicity profile. |
| Databáze: | OpenAIRE |
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