Inhibition by enkephalins of peristaltic activity of the rabbit ileum and its reversal by naloxone
| Autor: | Branka Terzić, D.B. Beleslin |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
medicine.medical_specialty Enkephalin Enkephalin Methionine Pharmaceutical Science Ileum (+)-Naloxone In Vitro Techniques chemistry.chemical_compound Internal medicine polycyclic compounds medicine Animals Receptor Peristalsis Pharmacology Gastrointestinal tract Methionine business.industry Naloxone digestive oral and skin physiology Enkephalins medicine.anatomical_structure Endocrinology nervous system chemistry Anesthesia Reflex Female Rabbits business Gastrointestinal Motility |
| Zdroj: | The Journal of pharmacy and pharmacology. 34(11) |
| ISSN: | 0022-3573 |
| Popis: | Two pentapeptides, the enkephalins have been isolated and identified from the mammalian gastrointestinal tract and have been shown to be potent opiate agonists (Hughes 1975; Lord et al 1977; Hughes et al 1977). Further work has demonstrated that methionine (met-)-enkephalin and D-Ala2-Leu-enkephalinamide affected the peristaltic reflex of the guinea-pig isolated ileum (van Nueten et al 1977; Kromer et al 1980). On the other hand, the rabbit isolated ileum has been scarcely used as model to study the peristaltic reflex (Feldberg & Lin 1949; Beleslin et al 1978). However, after evidence of the existence of met- and leucine (leu)-enkephalin as well as of enkephalin receptors in the rabbit intestine was reported (Hughes et al 1977; Oka 1980) it became interesting to investigate the action of enkephalins on the peristaltic activity of rabbit isolated ileum. |
| Databáze: | OpenAIRE |
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