Isolation of cytotoxic sesquiterpene lactones from the Tanacetopsis karataviensis (Kovalevsk.) Kovalevsk
Autor: | Bakhodir Tashkhodzhaev, R. F. Mukhamatkhanova, Shahnoz S Azimova, Dilnoza E Dusmatova, N. D. Abdullaev, Kambarali K. Turgunov, Khayrulla Bobakulov, Elena A Tsay, Ekaterina O Terenteva, I. D. Sham'yanov |
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Rok vydání: | 2019 |
Předmět: |
010405 organic chemistry
Stereochemistry Organic Chemistry Plant Science Isolation (microbiology) Sesquiterpene 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Cytotoxic T cell X ray analysis |
Zdroj: | Natural Product Research. 35:1939-1948 |
ISSN: | 1478-6427 1478-6419 |
Popis: | The structures and anticancer effects of two sesquiterpene lactones, 1 R,10S,3S,4R-diepoxyguai-5S,6S,7S-11(13)-en-6,12-olide (1) and hanphyllin (2) isolated from the aerial part of Tanacetopsis karataviensis (Kovalevsk.) Kovalevsk were investigated. The compound 1 was isolated for the first time as a natural compound and its structure was investigated by HR-ESI-MS, IR and NMR techniques. The X-ray diffraction analysis was performed to accurately determine the spatial structures of 1 and 2. Furthermore, we evaluated the cytotoxic activity of 1 and 2, and the chloroform fraction which contains both of them. Cytotoxic activity revealed that the effect of the chloroform fraction is stronger in growth inhibition of HeLa (89.7%) and HEp-2 (63.0%) cancer cells than the effect of individual compounds 1 (55.9 and 36.3%), 2 (78.6 and 50.3%) and the reference cisplatin (58.0 and 46.8%) respectively. Moreover, the chloroform fraction is less toxic to the hepatocytes. |
Databáze: | OpenAIRE |
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