The Central Role of Redox-Regulated Switch Proteins in Bacteria
| Autor: | Nora Lahrach, Marianne Ilbert, Dana Reichmann, Lisa Zuily, Rosi Fassler |
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| Přispěvatelé: | Institute of Chemistry, The Hebrew University of Jerusalem, The Hebrew University of Jerusalem (HUJ), Bioénergétique et Ingénierie des Protéines (BIP ), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Israel Science Foundation (1765/13 and 1537/18 for DR and RF), Human Frontier Science program (CDA00064/2014), the US-Israel Binational Science Foundation (2015056), ANR-19-CE44-0018,ChapCop,Rôle des protéines chaperons dans la survie bactérienne face à de fortes concentrations de cuivre(2019), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2021 |
| Předmět: |
redox-regulated proteins
Max-Planck-Gesellschaft (MPG) QH301-705.5 Mini Review [SDV]Life Sciences [q-bio] thiol-switches Hsp33 oxidative stress in prokaryotes Kürş ad Turgay metal induced oxidation medicine.disease_cause Biochemistry Genetics and Molecular Biology (miscellaneous) Biochemistry Redox 03 medical and health sciences Germany medicine oxidative stress Molecular Biosciences Biology (General) Molecular Biology Gene 030304 developmental biology chemistry.chemical_classification 0303 health sciences Reactive oxygen species Primary (chemistry) Mechanism (biology) 030302 biochemistry & molecular biology oxidative stress in prokaryotes Cell biology chemistry Proteome Oxidative stress |
| Zdroj: | Frontiers in Molecular Biosciences Frontiers in Molecular Biosciences, Frontiers Media, 2021, 8, ⟨10.3389/fmolb.2021.706039⟩ Frontiers in Molecular Biosciences, 2021, 8, ⟨10.3389/fmolb.2021.706039⟩ Frontiers in Molecular Biosciences, Vol 8 (2021) |
| ISSN: | 2296-889X |
| DOI: | 10.3389/fmolb.2021.706039 |
| Popis: | International audience; Bacteria possess the ability to adapt to changing environments. To enable this, cells use reversible post-translational modifications on key proteins to modulate their behavior, metabolism, defense mechanisms and adaptation of bacteria to stress. In this review, we focus on bacterial protein switches that are activated during exposure to oxidative stress. Such protein switches are triggered by either exogenous reactive oxygen species (ROS) or endogenous ROS generated as by-products of the aerobic lifestyle. Both thiol switches and metal centers have been shown to be the primary targets of ROS. Cells take advantage of such reactivity to use these reactive sites as redox sensors to detect and combat oxidative stress conditions. This in turn may induce expression of genes involved in antioxidant strategies and thus protect the proteome against stress conditions. We further describe the well-characterized mechanism of selected proteins that are regulated by redox switches. We highlight the diversity of mechanisms and functions (as well as common features) across different switches, while also presenting integrative methodologies used in discovering new members of this family. Finally, we point to future challenges in this field, both in uncovering new types of switches, as well as defining novel additional functions. |
| Databáze: | OpenAIRE |
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