Single Oral Challenge by Advanced Glycation End Products Acutely Impairs Endothelial Function in Diabetic and Nondiabetic Subjects
| Autor: | Weijing Cai, Helen Vlassara, M. Negrean, Jaime Uribarri, Theodore Koschinsky, Denise Sander, Cristina E. Buenting, Alin Stirban |
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| Rok vydání: | 2007 |
| Předmět: |
Glycation End Products
Advanced Acute effects medicine.medical_specialty Endothelium Endocrinology Diabetes and Metabolism Provocation test Administration Oral chemistry.chemical_compound Reference Values Glycation medicine.artery Diabetes mellitus Internal medicine Plasminogen Activator Inhibitor 1 Diabetes Mellitus Internal Medicine Humans Medicine Brachial artery Advanced and Specialized Nursing business.industry Vascular disease medicine.disease Endocrinology medicine.anatomical_structure chemistry Cardiovascular Diseases Plasminogen activator inhibitor-1 Endothelium Vascular business Diabetic Angiopathies |
| Zdroj: | Diabetes Care. 30:2579-2582 |
| ISSN: | 1935-5548 0149-5992 |
| Popis: | OBJECTIVE—The current study was designed to test the acute effects of dietary advanced glycation end products (AGEs) on endothelial function of diabetic and nondiabetic subjects. RESEARCH DESIGN AND METHODS—Flow-mediated dilation (FMD) of the brachial artery and serum levels of AGEs, plasminogen activator inhibitor 1 (PAI-1), vascular cell adhesion molecule 1 (VCAM-1), and glucose were assessed before and after a single oral AGE challenge (∼1.8 × 106 AGE units) in 44 diabetic and 10 nondiabetic subjects. RESULTS—The diabetic patients had higher baseline levels of serum AGEs (P = 0.020), PAI-1 (NS), and VCAM-1 (P = 0.033) and lower baseline values of FMD compared with nondiabetic subjects (P = 0.032). Ninety minutes after a single oral AGE challenge, serum AGEs and PAI-1 levels increased and FMD decreased significantly in both healthy subjects (AGEs: 7.2 ± 0.5 to 9.3 ± 1 units/ml, P = 0.014; PAI-1: 5.4 ± 0.4 to 6.8 ± 0.4 ng/ml, P = 0.007; and FMD: 9.9 ± 0.7 to 7.4 ± 0.9%, P = 0.019) and diabetic subjects (AGEs: 10.5 ± 0.7 to 14.2 ± 1 units/ml, P = 0.020; PAI-1: 6.5 ± 1 to 10 ± 2 ng/ml, P = 0.030; and FMD: 5.4 ± 0.4 to 4.0 ± 0.3%, P = 0.032). Serum glucose and VCAM-1 levels remained unchanged. CONCLUSIONS—Significant increases in serum AGEs can occur together with altered clinical measures of endothelial function in diabetic and nondiabetic subjects after a single modest AGE-rich beverage. Thus, repeated or chronic exposure to high AGE diets could over time lead to and/or accelerate vascular disease. |
| Databáze: | OpenAIRE |
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