The bex locus in encapsulated Haemophilus influenzae: a chromosomal region involved in capsule polysaccharide export
| Autor: | L. N. Brophy, E R Moxon, J. S. Kroll, B M Loynds |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
DNA
Bacterial Protein Conformation Molecular Sequence Data Restriction Mapping Locus (genetics) Biology medicine.disease_cause Microbiology Haemophilus influenzae Open Reading Frames Plasmid Bacterial Proteins medicine Escherichia coli Amino Acid Sequence Molecular Biology Gene Peptide sequence Genetics Base Sequence Polysaccharides Bacterial Nucleic acid sequence Membrane Transport Proteins Chromosomes Bacterial Open reading frame Mutagenesis Insertional Genes Bacterial Chromosomal region ATP-Binding Cassette Transporters Plasmids |
| Zdroj: | Molecular microbiology. 4(11) |
| ISSN: | 0950-382X |
| Popis: | The nucleotide sequence of a 5.1 kb region in the Haemophilus influenzae type b capsulation locus has been determined and found to contain four open reading frames: bexD, bexC, bexB, and bexA. Comparison of the deduced products of bexC, bexB, and bexA to known proteins, and TnphoA mutagenesis, suggests that they form components of an ATP-driven polysaccharide export apparatus. Furthermore, close sequence similarity between BexA and BexB and products of the kpsT and kpsM genes at the Escherichia coli K5 capsulation locus (Smith et al., 1990--accompanying paper) suggests that capsulation genes in these organisms may have a common ancestry. |
| Databáze: | OpenAIRE |
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