Microscopic polyangiitis with unusual lung involvement
| Autor: | ÖZlemÖzdemir Kumbasar, D. Alper, Mutlu Gülbay, Banu Eriş Gülbay, Özden Tulunay, Gökhan Çelik |
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| Rok vydání: | 2005 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Lung Diseases Male Vasculitis Pathology medicine.medical_specialty Cyclophosphamide medicine.drug_class medicine.medical_treatment Antibodies Antineutrophil Cytoplasmic chemistry.chemical_compound Fatal Outcome medicine Humans Mechanical ventilation Creatinine medicine.diagnostic_test business.industry Glomerulosclerosis Focal Segmental medicine.disease Respiratory failure chemistry Corticosteroid Renal biopsy business Microscopic polyangiitis Infiltration (medical) Biomarkers medicine.drug |
| Zdroj: | Respirology (Carlton, Vic.). 10(5) |
| ISSN: | 1323-7799 |
| Popis: | Microscopic polyangiitis (MPA) is a non-granulomatous, systemic and small vessel vasculitis accompanied by segmental necrotizing glomerulonephritis with no evidence of other small vessel disease. We report a patient with weakness, fever, and arthralgia whose CXR and thoracic CT showed widespread nodular infiltration. His proteinase-3 anti-neutrophilic cytoplasmic antibody (c-ANCA) was positive. The serum creatinine was increased and haematuria subsequently developed. Renal biopsy revealed a focal segmental necrotizing glomerulonephritis which was compatible with MPA. He was treated with high-dose corticosteroid and cyclophosphamide. Because of a worsening CXR and hypoxaemia, mechanical ventilation was applied. Despite this he died of respiratory failure following 20 days of treatment. Nodular infiltration is an unusual radiological pattern in patients with MPA and is the reason for this report. |
| Databáze: | OpenAIRE |
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