Longitudinal changes in bone parameters in young girls with anorexia nervosa
| Autor: | Charlotte Oakley, Michelle Thrower, Helen McDevitt, Sheila Shepherd, Avril Mason, S Faisal Ahmed, Andreas Kyriakou, M G Shaikh |
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| Rok vydání: | 2018 |
| Předmět: |
Anorexia Nervosa
Histology Adolescent Bone density Physiology Endocrinology Diabetes and Metabolism Dentistry 030209 endocrinology & metabolism Bone and Bones Young Adult 03 medical and health sciences Absorptiometry Photon 0302 clinical medicine Bone Density Humans Medicine Longitudinal Studies 030212 general & internal medicine Bone mineral business.industry Anthropometry medicine.disease Obesity Anorexia nervosa (differential diagnoses) Multivariate Analysis Body Composition Lean body mass Regression Analysis Female Lumbar spine business Body mass index Follow-Up Studies |
| Zdroj: | Bone. 116:22-27 |
| ISSN: | 8756-3282 |
| DOI: | 10.1016/j.bone.2018.03.022 |
| Popis: | Background:\ud Anorexia nervosa (AN) during childhood and adolescence has been reported to adversely affect bone health, but few studies have investigated longitudinal changes.\ud \ud Method:\ud DXA-derived bone parameters and body composition were retrospectively assessed in 111 young girls with AN with a median age of 15.4 years (10.9, 19.8). In 68 (61%) vertebral fracture assessment (VFA) was performed and in 31 (28%), a follow-up DXA was performed. Correlations with growth, changes in body composition and effects of illness duration and menstruation were examined. Size adjusted DXA standard deviation scores were calculated for total body (TB) less head bone mineral content (TBLH-BMC) and lumbar spine bone mineral apparent density (LS-BMAD).\ud \ud Results:\ud Mean (range) bone area (BA) for height centile was 27.1 (0–97), and mean lean mass for height centile was 28.8 (0–95) at baseline. Mean (range) LS BMAD was −1.0 (−2.6, 0.8) SDS at first and − 1.2 (−3.0, −0.2) at second DXA (p = 0.023). On follow up, lean mass for height increased from 27th centile (0, 75) to 40th centile (0, 70) (p = 0.006), and fat mass for height increased from 55 g/cm to 67 g/cm (11.3, 124.2) (p |
| Databáze: | OpenAIRE |
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