Accuracy of the Informant Questionnaire on Cognitive Decline in the Elderly for Detecting Preexisting Dementia in Transient Ischemic Attack and Stroke
| Autor: | Astrid C. van Nieuwkerk, Sarah T. Pendlebury, Peter M. Rothwell |
|---|---|
| Přispěvatelé: | Study, Oxford Vascular |
| Rok vydání: | 2021 |
| Předmět: |
Male
Gerontology Article 03 medical and health sciences 0302 clinical medicine Informant Questionnaire on Cognitive Decline in the Elderly Surveys and Questionnaires Humans Medicine Dementia Cognitive Dysfunction Transient (computer programming) 030212 general & internal medicine Stroke Aged Aged 80 and over Advanced and Specialized Nursing business.industry Medical record Cognition Middle Aged medicine.disease Population based study Ischemic Attack Transient Female Neurology (clinical) Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery |
| Zdroj: | Stroke |
| ISSN: | 1524-4628 0039-2499 |
| DOI: | 10.1161/strokeaha.120.031961 |
| Popis: | Background and Purpose: Prestroke dementia prevalence is high and impacts outcome. Although the IQCODE (Informant Questionnaire on Cognitive Decline in the Elderly) is being used to assess prestroke cognition, data on its validity for prestroke dementia are lacking. We studied the accuracy of the short-form (16-item) IQCODE for pre-event dementia in a population-based study of all transient ischemic attack (TIA)/stroke. Methods: All patients with TIA/stroke in a defined population of ≈92 720 (Oxford Vascular Study, 2002–2017) with IQCODE were included. IQCODE questionnaires were given to participants at baseline interview with instructions to pass to an informant for completion and return by post. Diagnosis of pre-event dementia was defined as prior diagnosis of dementia, or dementia by the Diagnostic and Statistical Manual of Mental Disorders-IV criteria on study interview and hand-searching of the entire medical record blinded to IQCODE. Reliability of the IQCODE for dementia was determined by the area under the receiver operating characteristic curve, sensitivity and specificity, stratified by age, event severity, and first-ever stroke. Results: Among 2059 interviewed survivors, IQCODE were returned in 1068 (mean age/SD=72.9/12.3, 47% TIA, 52.3% male, 68 [6.4%] pre-event dementia). Area under the receiver operating characteristic curve for IQCODE for pre-event dementia was 0.94 (95% CI, 0.90–0.97, P 3.48 (sensitivity=89.7%; specificity=84.2%) but was nonsignificantly higher for major stroke (National Institutes of Health Stroke Scale score ≥3) than minor stroke/TIA (>3.85 versus >3.47). Performance was similar in patients with first-ever stroke (area under the receiver operating characteristic curve, 0.92 [0.88–0.97]; sensitivity=85.7%; specificity=84.8% for cutoff >3.48). All 16-IQCODE questions discriminated between dementia and no dementia (all P Conclusions: IQCODE has excellent accuracy for detecting preexisting dementia in TIA and stroke with the pattern of deficits suggesting prominent executive dysfunction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|