National pharmacological treatment trends for ankylosing spondylitis in South Korea: A national health insurance database study

Autor: Yong-Chol Kwon, Jin-Sung Park, Sang-Hee Kim, Jae-Young Hong, Hak-Kyu Kim, Bongmo Koo
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Databases
Factual
National Health Programs
NSAIDs
Economics
Physiology
Ankylosing Spondylitis
Cancer Treatment
Social Sciences
Datasets as Topic
Geographical locations
0302 clinical medicine
Immune Physiology
Prospective Studies
Young adult
Prospective cohort study
Child
Aged
80 and over
Analgesics
Innate Immune System
Multidisciplinary
Pharmaceutics
Anti-Inflammatory Agents
Non-Steroidal
Age Factors
Drugs
Middle Aged
Oncology
Antirheumatic Agents
Medicine
Cytokines
Drug Therapy
Combination
Female
Research Article
Adult
medicine.medical_specialty
Asia
Combination therapy
Adolescent
Science
Immunology
MEDLINE
Drug Prescriptions
Autoimmune Diseases
03 medical and health sciences
Young Adult
Pharmacotherapy
Health Economics
Drug Therapy
Rheumatology
Internal medicine
South Korea
Republic of Korea
medicine
Humans
Spondylitis
Ankylosing
Medical prescription
Spondylitis
Aged
030203 arthritis & rheumatology
Medicine and health sciences
Pharmacology
Ankylosing spondylitis
Biological Products
business.industry
Tumor Necrosis Factor-alpha
Arthritis
Biology and Life Sciences
Molecular Development
medicine.disease
Pain management
Health Care
030104 developmental biology
Immune System
Clinical Immunology
Clinical Medicine
People and places
business
Health Insurance
Developmental Biology
Zdroj: PLoS ONE
PLoS ONE, Vol 15, Iss 10, p e0240155 (2020)
ISSN: 1932-6203
Popis: No studies of the current status of treatment options are available for ankylosing spondylitis (AS) patients in South Korea. This study assesses the current status of AS treatment trends using a nationwide database. This study was conducted using a Korean National Health Insurance System (KNHIS) dataset from 2006 to 2016. We randomly extracted 50% of the total number of patients registered as As patients in the KNHIS. The distribution of the number of patients according to age and gender was analyzed each year. The types and combination methods of drugs used during the study period were estimated yearly. Between 2006 and 2016, the number of AS patients increased linearly by an average of 9% annually, 6372 in 2006 to 15188 in 2016. The study found that the use of nonsteroidal anti-inflammatory drugs (NSAIDs) was the most commonly prescribed pharmacological treatment option, followed by disease-modifying anti-rheumatic drugs (DMARDs) and then biologics. Biologics such as tumor necrosis factor alpha (TNF-α) inhibitors increased from 10% to 35% consistently for 10 years. In terms of combination therapy, DMARDs + NSAIDs accounted for almost 90% of treatments in 2006, but decreased by 65% in 2016. The use of biologics and NSAIDs increased from 3% to 28%. Prescriptions for dual therapies and mono therapies largely dominated prescription habits, accounted for up to approximately 80% of treatments. Among 10- to 14-year-old patients, there was no triple therapy, dual and triple therapies decreased gradually for those 60 and older, and the ratio of conservative treatments has increased. This study shows how South Korea reflects changes in AS treatment trends, along with the emergence of TNF-α inhibitors that are effective in treating AS. Research on clinical outcomes for AS treatments will be needed on following these drug changes.
Databáze: OpenAIRE
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