The Prognosis of Arthrofibroses: Prevalence, Clinical Shortcomings, and Future Prospects
| Autor: | William A. Blessing, Amanda K. Williamson, Jack Kirsch, Mark W. Grinstaff |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Knee Joint Connective tissue Disease Toxicology Bioinformatics Article 03 medical and health sciences 0302 clinical medicine Fibrosis medicine Prevalence Animals Joint immobilization Arthrofibrosis Pharmacology Biological studies business.industry medicine.disease Prognosis Clinical trial 030104 developmental biology medicine.anatomical_structure Joint Diseases business Biochemical function 030217 neurology & neurosurgery |
| Zdroj: | Trends Pharmacol Sci |
| Popis: | Fibrosis is the dysregulated biosynthesis of connective tissue that arises as a consequence of persistent infection, high serum cholesterol, surgery, trauma, or prolonged joint immobilization. As a disease that impacts connective tissue, it is prevalent across the body and disrupts normal extracellular and tissue organization. Ultimately, fibrosis impairs the tissue structural, mechanical, or biochemical function. This review describes the clinical landscape of joint fibrosis, i.e., arthrofibrosis, including the risk factors and causes, as well as current clinical treatments and their shortcomings. As treating arthrofibrosis remains an unmet clinical challenge, we then present several animal models used for exploration of the physiopathology of arthrofibrosis and summarize their use for testing novel treatments. Next, we discuss therapeutics for the prevention or treatment of arthrofibrosis in preclinical development and those in ongoing clinical trials. We conclude with recent findings from molecular biology studies of arthrofibroses that shed insight on future areas of research for improved treatment. |
| Databáze: | OpenAIRE |
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