Mechanical testing methods for drug-releasing vaginal rings
| Autor: | Clare McCoy, Wendy Blanda, Bronagh Millar, Bashir Hansraj, Brid Devlin, R. Karl Malcolm, Diarmaid J. Murphy, Peter Boyd |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Computer science Anti-HIV Agents Pharmaceutical Science International partnership Contraceptive Devices Female HIV Infections 02 engineering and technology 021001 nanoscience & nanotechnology 030226 pharmacology & pharmacy Microbicides for sexually transmitted diseases 03 medical and health sciences Administration Intravaginal 0302 clinical medicine Drug Delivery Systems SDG 3 - Good Health and Well-being Hormone regulation medicine Compression test Medical physics Stress Mechanical 0210 nano-technology Hiv transmission |
| Zdroj: | McCoy, C F, Millar, B G, Murphy, D J, Blanda, W, Hansraj, B, Devlin, B, Malcolm, R K & Boyd, P 2019, ' Mechanical testing methods for drug-releasing vaginal rings ', International Journal of Pharmaceutics, vol. 559, pp. 182-191 . https://doi.org/10.1016/j.ijpharm.2019.01.026 |
| DOI: | 10.1016/j.ijpharm.2019.01.026 |
| Popis: | Vaginal rings (VRs) are currently marketed for contraceptive or hormone regulation purposes, and investigationally, have been widely reported for delivery of antiretrovirals to reduce HIV transmission. To date, there is no national or international standard for the mechanical testing and minimum performance characteristics of any VR based products. Here, we describe a a series of mechanical tests examining the durometer hardness, static and dynamic compression response, tensile properties and twist resistance of vaginal rings. The tests were conducted on currently marketed VRs and a number of the International Partnership for Microbicides’ (IPM) investigational VR formulations. With wider application in the field, the tests described herein could form the basis for a more standardised approach to the mechanical testing of VRs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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