Fatal case of donor-derived colistin-resistant carbapenemase-producing Klebsiella pneumoniae transmission in cardiac transplantation
| Autor: | Lisia Miglioli Galvão, Aline Santos Ibanes, Fernanda Inoue, Anna Paula Romero de Oliveira, Jussimara Monteiro, Cely S. Abboud, Daniel Wagner de Castro Lima Santos, Flavio Sánchez, Daniel Chagas Dantas |
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| Jazyk: | angličtina |
| Předmět: |
0301 basic medicine
Microbiology (medical) Male Klebsiella pneumoniae medicine.medical_treatment 030106 microbiology lcsh:QR1-502 030230 surgery lcsh:Microbiology Microbiology Carbapenem-resistant lcsh:Infectious and parasitic diseases 03 medical and health sciences Pericarditis 0302 clinical medicine Fatal Outcome Risk Factors Drug Resistance Multiple Bacterial medicine polycyclic compounds Humans lcsh:RC109-216 Heart transplantation biology Septic shock business.industry Colistin Osteomyelitis Middle Aged biochemical phenomena metabolism and nutrition medicine.disease biology.organism_classification bacterial infections and mycoses Tissue Donors Transplant Recipients Anti-Bacterial Agents Klebsiella Infections Transplantation Infectious Diseases Carbapenem-Resistant Enterobacteriaceae Amikacin Heart Transplantation Cardiac transplantation business Donor-derived infection medicine.drug |
| Zdroj: | Brazilian Journal of Infectious Diseases, Vol 22, Iss 3, Pp 235-238 Brazilian Journal of Infectious Diseases, Vol 22, Iss 3, Pp 235-238 (2018) |
| ISSN: | 1678-4391 |
| Popis: | Herein we report a fatal case of donor-derived transmission of XDR-resistant carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) in cardiac transplantation. A 59-year-old male patient with non-obstructive hypertrophic cardiomyopathy underwent heart transplantation. On day 5 post-operation, blood cultures from the donor were positive for colistin-resistant carbapenemase-producing K. pneumoniae (ColR KPC-Kp) susceptible only to amikacin. Recipient blood cultures were also positive for ColR KPC-Kp with the same sensitivity profile as the donor isolate with an identical PFGE pattern. The patient was treated with double-carbapenems and amikacin. The patient evolved to pericarditis, osteomyelitis, and pulmonary necrosis, all fragment cultures positive for the same agent. The patient developed septic shock, multiple organ failure and died on day 50 post-transplantation. Based on current microbiological scenario worldwide the possibility of transmitting multidrug resistant (MDR) organisms should be considered. Keywords: Cardiac transplantation, Klebsiella pneumoniae, Donor-derived infection, Carbapenem-resistant |
| Databáze: | OpenAIRE |
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