Renin-angiotensin axis blockade reduces proteinuria in presymptomatic patients with familial FSGS
| Autor: | Lawrence Copelovitch, Martin R. Pollak, Bernard S. Kaplan, Marta Guttenberg |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Nephrology medicine.medical_specialty Adolescent Urology Renal function urologic and male genital diseases Podocyte TRPC6 Renin-Angiotensin System Focal segmental glomerulosclerosis Internal medicine Renin–angiotensin system Humans Medicine Child Hematuria Proteinuria Glomerulosclerosis Focal Segmental urogenital system business.industry medicine.disease female genital diseases and pregnancy complications Blockade medicine.anatomical_structure Pediatrics Perinatology and Child Health Immunology Female medicine.symptom business Immunosuppressive Agents |
| Zdroj: | Pediatric Nephrology. 22:1779-1784 |
| ISSN: | 1432-198X 0931-041X |
| Popis: | Familial and genetic forms of focal segmental glomerulosclerosis (FSGS) are associated with six different mutations in genes affecting the podocyte (NPHS2, ACTN4, CD2AP, WT1, TRPC6, and PLCE1). Immunosuppressive agents are often unsuccessful in treating this condition. Data regarding the efficacy of renoprotection through blockage of the renin-angiotensin axis is lacking. We describe three children from two different families with familial FSGS in whom partial to complete remission of proteinuria was attained through early blockade of the renin-angiotensin axis. In addition, there was no deterioration of renal function. We speculate that presymptomatic patients with normal renal function who have genetic or familial FSGS may benefit from early blockade of the renin-angiotensin axis and that this may also prevent progressive renal disease. |
| Databáze: | OpenAIRE |
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