Effets et métabolismes spécifiques des acides gras ω3
| Autor: | Michel Lagarde, Evelyne Véricel |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Antioxidant Thromboxane Linolenic acid medicine.medical_treatment lcsh:TP670-699 Prostacyclin medicine.disease_cause Biochemistry Lipid peroxidation chemistry.chemical_compound Internal medicine arachidonic acid medicine Chemistry Metabolism Endocrinology inflammation eicosapentaenoic and docosahexaenoic acids lipids (amino acids peptides and proteins) Arachidonic acid cardiovascular protection lcsh:Oils fats and waxes Oxidative stress Food Science medicine.drug |
| Zdroj: | Oléagineux, Corps gras, Lipides, Vol 11, Iss 1, Pp 55-57 (2004) |
| ISSN: | 1950-697X 1258-8210 |
| DOI: | 10.1051/ocl.2004.0055 |
| Popis: | Omega 3 fatty acids are issued from linolenic acid (18:3ω3). Nutritional interest about ω3 fatty acids has begun since the epidemiological studies of Dyerberg et al. have shown a relationship between consumption of marine fats and reduction of cardiovascular diseases. Long-chain ω3 fatty acids, mainly eicosapentaenoic (20:5ω3 or EPA) and docosahexaenoic (22:6ω3 or DHA) acids, are considered to be the main bioactive components in marine sources. Other studies have confirmed that consumption of fish ou EPA\\DHA supplements may reduce mortality in patients who have suffered from myocardial infarction. Beneficial effects of ω3 fatty acids are also recognized in inflammatory disorders. The main mechanism involved for those effects is assumed to be the interference between long-chain ω3 fatty acids and the arachidonic acid (AA) metabolism in blood and vascular cells. In those cells, AA may be released from membrane phospholipids by phospholipase A 2 and subsequently oxygenated into eicosanoids (overall called AA cascade). According to the cell, oxygenated products from AA include thromboxane (platelets), prostacyclin (endothelial cells) and leukotrienes (leukocytes). EPA and DHA can interfere with AA cascade by several ways to reduce the vascular risk. However, high intake of such fatty acids may increase lipid peroxidation and have deleterious effects, in particular in subjects suffering from oxidative stress, whereas law may exert “antioxidant” activity. We conclude that a moderate consumption of long-chain ω3 fatty acids can protect against cardiovascular dysfunction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|