Functional connectivity during cognitive control in children with autism spectrum disorder: an independent component analysis
| Autor: | Bob Oranje, Sara Ambrosino, T. van Raalten, Dienke J. Bos, J. van Belle, Sarah Durston, N. A. Kobussen |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Multivariate statistics Multivariate analysis Adolescent Clinical Neurology Neuropsychological Tests Brain mapping ASD Task (project management) Executive Function Functional connectivity Cognition Neural Pathways medicine Humans ICA Child Biological Psychiatry Brain Mapping medicine.diagnostic_test Psychiatry and Preclinical Psychiatric Studies - Original Article Brain Signal Processing Computer-Assisted medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Neurology Autism spectrum disorder Child Development Disorders Pervasive Multivariate Analysis Cognitive control Autism Neurology (clinical) Psychology Functional magnetic resonance imaging Rigid behavior Cognitive psychology |
| Zdroj: | Journal of Neural Transmission |
| ISSN: | 1435-1463 |
| Popis: | Restrictive and repetitive behavior in autism may be related to deficits in cognitive control. Here, we aimed to assess functional connectivity during a cognitive control task and compare brain network activity and connectivity in children with autism spectrum disorders (ASD) and typically developing children using a multivariate data-driven approach. 19 high-functioning boys with ASD and 19 age-matched typically developing boys were included in this study. Functional magnetic resonance imaging was performed at 3T during the performance of a cognitive control task (go/no-go paradigm). Functional networks were identified using independent component analysis. Network activity and connectivity was compared between groups and correlated with clinical measures of rigid behavior using multivariate analysis of covariance. We found no differences between the groups in task performance or in network activity. Power analysis indicated that, if this were a real difference, it would require nearly 800 subjects to show group differences in network activity using this paradigm. Neither were there correlations between network activity and rigid behavior. Our data do not provide support for the presence of deficits in cognitive control in children with ASD, or the functional networks supporting this ability. Electronic supplementary material The online version of this article (doi:10.1007/s00702-014-1237-8) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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