From acinar cell damage to systemic inflammatory response: Current concepts in pancreatitis
| Autor: | Christoph K. Weber, Guido Adler |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Pathology
medicine.medical_specialty Endocrinology Diabetes and Metabolism Inflammatory response Inflammation Disease Bioinformatics Acinar cell Animals Humans Medicine Trypsin Cytoskeleton Immunity Cellular Hepatology business.industry NF-kappa B Gastroenterology medicine.disease Pathophysiology Pancreatitis Acute pancreatitis Calcium Inflammation Mediators medicine.symptom business Inflammatory disorder |
| Zdroj: | Pancreatology. 1:356-362 |
| ISSN: | 1424-3903 |
| Popis: | Acute pancreatitis represents a local inflammatory disorder with severe systemic consequences. Significant progress in understanding the pathophysiology of acute pancreatitis has been achieved in recent years. However, there is no clear concept about initialization and propagation of the disease both in experimental models and in humans. Furthermore, reliable strategies to evaluate prognosis and perform therapy are still missing. The review focuses on mechanisms originating from acinar cells leading to a systemic inflammatory response in experimental pancreatitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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