Cytokine Gene Polymorphisms in Saudi Patients With Atopic Dermatitis: A Case-Control Study
| Autor: | Fahad Al Harthi, Sadaf Rizvi, Misbahul Arfin, Abdulrahaman Al-Asmari, Mohammed Al-Sugheyr, Ghaleb Bin Huraib |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment tumor necrosis factor interleukin-10 Saudi polymorphism 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Polymorphism (computer science) Genotype Medicine Risk factor Allele Original Research Atopic dermatitis Pharmacology lcsh:R5-920 business.industry Biochemistry (medical) Case-control study medicine.disease Interleukin 10 030104 developmental biology Cytokine Immunology Molecular Medicine business lcsh:Medicine (General) |
| Zdroj: | Biomarker Insights, Vol 13 (2018) Biomarker Insights |
| ISSN: | 1177-2719 |
| Popis: | The cause of atopic dermatitis (AD) is multifactorial and a number of genes including cytokines have been involved. We genotyped 315 subjects for polymorphisms in TNF-α and TNF-β and IL-10 genes. Patients had significantly higher frequency of GA genotype of TNF-α (−308 G/A) than healthy controls. Patients with AD and controls had similar distribution of A and G alleles. Genotype AA was found in 7.11% of controls while completely absent in cases. The frequencies of genotypes GG and AA of TNF-β (+252 A/G) polymorphism were higher whereas the frequency of genotype GA was significantly lower in patients than the controls. The frequencies of genotypes GG and AA of IL-10 (1082 G/A) polymorphism were significantly increased whereas genotype GA was decreased in patients than the controls. It is concluded that TNF-α (−308 G/A), TNF-β (+252 A/G), and IL-10 (−1082 G/A) polymorphisms are linked with the susceptibility of AD in Saudis and can be a risk factor. |
| Databáze: | OpenAIRE |
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