Co-localization of polar replication fork barriers and rRNA transcription terminators in mouse rDNA
| Autor: | Pablo E. Hernández, Carlos López-Estraño, Jorge Bernardo Schvartzman, Dora B. Krimer |
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| Přispěvatelé: | Dirección General de Enseñanza Superior e Investigación Científica (España), Instituto de Salud Carlos III, Consejo Nacional de Investigaciones Científicas y Tecnológicas (Venezuela), Schvartzman, Jorge Bernardo [0000-0002-1856-6278], Krimer, Dora B. [0000-0001-9972-3994], Hernandez, Pablo [0000-0002-8113-1277], Schvartzman, Jorge Bernardo, Krimer, Dora B., Hernandez, Pablo |
| Rok vydání: | 1998 |
| Předmět: |
DNA Replication
Thyroid Nuclear Factor 1 Replication fork barrier Biology DNA Ribosomal Mice chemistry.chemical_compound Co localization Structural Biology Transcription (biology) Tumor Cells Cultured Animals Molecular Biology Terminator Regions Genetic Genetics Transcription termination Ter protein Nuclear Proteins RNA Replication termination RRNA transcription Mouse rDNA Replication fork arrest chemistry RNA Ribosomal DNA Transcription Factors |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 0022-2836 |
| DOI: | 10.1006/jmbi.1997.1607 |
| Popis: | 8 p.-7 fig. We investigated the replication of the region where transcription terminates in mouse rDNA. It contains a replication fork barrier (RFB) that behaves in a polar manner, arresting only replication forks moving in the direction opposite to transcription. This RFB consists of several closely spaced fork arrest sites that co-localize with the transcription terminator elements, known as Sal boxes. Sal boxes are the target for mTTF-I (murine transcription termination factor I). These results suggest that both termination of rRNA transcription and replication fork arrest may share cis-acting as well as trans-acting factors. This work was partially supported by grant PM95-0016 from the Spanish Dirección General de Enseñanza Superior, grant 96/0470 from the Spanish Fondo de Investigación Sanitaria and a fellowship of the Consejo Nacional de Investigaciones Científicas y Tecnológicas (Venezuela) to C.L.-E. |
| Databáze: | OpenAIRE |
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