A microfluidic device for real-time on-demand intravenous oxygen delivery

Autor:	Ashwin Kumar Vutha, Ryan Patenaude, Alexis Cole, Rajesh Kumar, John N. Kheir, Brian D. Polizzotti
Rok vydání:	2022
Předmět:	Oxygen Extracorporeal Membrane Oxygenation Ventilators Mechanical Multidisciplinary Lab-On-A-Chip Devices Humans Lung Injury Hypoxia
Zdroj:	Proceedings of the National Academy of Sciences. 119
ISSN:	1091-6490 0027-8424
DOI:	10.1073/pnas.2115276119
Popis:	Significance The treatment of hypoxemia that is refractory to the current standard of care is time-sensitive and requires skilled caregivers and use of specialized equipment (e.g., extracorporeal membrane oxygenation). Most patients experiencing refractory hypoxemia will suffer organ dysfunction, and death is common in this cohort. Here, we describe a new strategy to stabilize and support patients using a microfluidic device that administers oxygen gas directly to the bloodstream in real time and on demand using a process that we call sequential shear-induced bubble breakup. If successful, the described technology may help to avoid or decrease the incidence of ventilator-related lung injury from refractory hypoxemia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b9cd55ad792034e37fe89d3a2bb15c https://doi.org/10.1073/pnas.2115276119 Zobrazit plný text záznamu