Genetic variation in leptin and leptin receptor genes as a risk factor for idiopathic male infertility
Autor: | Alenka Hodžić, Ivana Novakovic, Branko Zorn, Dijana Plaseska-Karanfilska, Aleš Maver, Cane Tulic, Borut Peterlin, Momcilo Ristanovic |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Adult Leptin Male Genotype Urology Endocrinology Diabetes and Metabolism education Population Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Male infertility 03 medical and health sciences 0302 clinical medicine Endocrinology Gene Frequency Polymorphism (computer science) Risk Factors Genetic variation medicine Humans Genetic Predisposition to Disease Genetic variability Alleles Genetic Association Studies Infertility Male Genetics education.field_of_study 030219 obstetrics & reproductive medicine Leptin receptor Sperm Count Middle Aged medicine.disease Republic of North Macedonia 030104 developmental biology Reproductive Medicine Case-Control Studies Receptors Leptin Serbia hormones hormone substitutes and hormone antagonists |
Zdroj: | Andrology. 5(1) |
ISSN: | 2047-2927 |
Popis: | Summary The aim of this study was to examine whether there is an association among genetic variability in leptin (LEP) and leptin receptor (LEPR) genes and male infertility. We performed a case–control study and were searching for an association between polymorphisms of LEP and LEPR genes and male infertility. The study group consisted of 317 patients with idiopathic infertility and a control group of 241 fertile men from Slovenia. Four single nucleotide polymorphisms (SNPs) in LEP gene and four single nucleotide polymorphisms (SNPs) in LEPR gene were chosen and genotyped. Statistically significant SNP was further validated in additional 255 infertile patients and 168 controls from Serbia and Macedonia. In the Slovenian population, we found a statistically significant difference in genotype distribution for rs10244329 polymorphism in LEP gene (recessive genotype model, p value = 0.048). The trend toward statistically significant difference in genotype distribution for rs10244329 polymorphism was confirmed in the Serbian and Macedonian populations (p value = 0.07). Our data suggest that genetic variability in the LEP gene might be associated with male infertility warranting further confirmation and mechanistic investigations. |
Databáze: | OpenAIRE |
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