Early thrombin generation and impaired fibrinolysis after SCT associate with acute GVHD
| Autor: | Jussi Oskari Virtanen, Riitta Lassila, Tapani Ruutu, Liisa Volin, M. Lemponen, A Pinomäki, Lotta Joutsi-Korhonen |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Adolescent medicine.medical_treatment Graft vs Host Disease Pilot Projects Thrombin time Thrombomodulin Fibrin Young Adult 03 medical and health sciences 0302 clinical medicine Thrombin immune system diseases Plasminogen Activator Inhibitor 1 Fibrinolysis medicine Humans Disseminated intravascular coagulation Transplantation medicine.diagnostic_test biology business.industry Hematopoietic Stem Cell Transplantation Hematology Middle Aged medicine.disease 3. Good health Transplantation Isogeneic surgical procedures operative Graft-versus-host disease Tissue Plasminogen Activator 030220 oncology & carcinogenesis Immunology biology.protein Female business Follow-Up Studies 030215 immunology medicine.drug |
| Zdroj: | Bone Marrow Transplantation. 45:730-737 |
| ISSN: | 1476-5365 0268-3369 |
| DOI: | 10.1038/bmt.2009.227 |
| Popis: | The evolution of coagulation and fibrinolysis has not been thoroughly evaluated in allogeneic SCT. In this pilot study, we characterized the adaptive mechanisms of coagulation and fibrinolysis during allogeneic SCT and 3-month follow-up and studied possible associations with outcome, including acute GVHD. Thirty patients underwent SCT for a haematological malignancy after myeloablative conditioning. Nineteen patients received the transplant from an HLA-identical sibling and 11 from an unrelated donor. GVHD prophylaxis consisted of CYA and MTX, with methylprednisolone in sibling transplants. Serial coagulation and fibrinolytic activity markers were assessed, including prothrombin fragments 1+2 (F1+2), thrombin time, D-dimer, tissue-type plasminogen-activator (tPA) and plasminogen-activator inhibitor (PAI-1). Early during conditioning therapy, F1+2 and D-dimer increased threefold indicating thrombin generation and fibrin turnover. TPA activity peaked before engraftment, concurring with diminished PAI-1. At 10 days after transplantation shortened thrombin time ( |
| Databáze: | OpenAIRE |
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