Alginate microparticles for enzyme peroral administration
| Autor: | Maria Teresa Bernabei, Valentina Iannuccelli, Riccardo Cameroni, Gilberto Coppi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Alginates
Drug Compounding Pharmaceutical Science Salt (chemistry) Dosage form Excipients chemistry.chemical_compound alginate Microparticle Lactose Desiccation chemistry.chemical_classification Chromatography biology L-Lactate Dehydrogenase Polyacrylic acid Alginate spray-drying oral delivery protein activity preservation Enzyme assay Microspheres Solutions enzyme Enzyme chemistry Biochemistry biology.protein peroral administration Drug carrier Rheology |
| Popis: | In order to protect protein and peptide drugs against inactivation by different barriers in the gastro-intestinal tract and to improve their absorption, alginate microparticles as a carrier of L-lactate dehydrogenase, were developed by spray-drying technique. However, alginate complexation and spray-drying conditions led to enzyme activity loss. Such a drawback was overcome by using protectant additives (carboxymethylcellulose sodium salt, polyacrylic acid sodium salt, lactose) preventing the enzyme inactivation by both interaction with alginate and experimental conditions, lactose having the most protective effect. Nevertheless, only polyacrylic acid sodium salt provided a microparticulate structure required for the target of the Peyer's patches. |
| Databáze: | OpenAIRE |
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