Alteration of tooth movement by reveromycin A in osteoprotegerin-deficient mice
| Autor: | Mamoru Yoshizako, Hatsuhiko Maeda, Miyuki Hirano, Ken Miyazawa, Hiroyuki Osada, Takuma Sato, Yuichirou Asano, Shigemi Goto, Masako Tabuchi, Chisato Minamoto, Manami Mizuno, Yasuyoshi Torii, Makoto Kawatani |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Tooth Movement Techniques medicine.medical_treatment Osteoporosis Osteoclasts Orthodontics Bone remodeling 03 medical and health sciences Mice 0302 clinical medicine Osteoprotegerin Osteoclast Internal medicine medicine Animals Spiro Compounds Dental alveolus Pyrans business.industry 030206 dentistry Bisphosphonate medicine.disease Discontinuation medicine.anatomical_structure Endocrinology Bone Remodeling Osteonecrosis of the jaw business 030217 neurology & neurosurgery |
| Zdroj: | American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics. 157(5) |
| ISSN: | 1097-6752 |
| Popis: | Introduction Osteoprotegerin-deficient mice develop severe high-turnover osteoporosis with porous low-density trabecular bone from an age-related increase in osteoclast activity and are useful alveolar bone models of osteoporosis or frail periodontal tissue. Bisphosphonate (BP), a first-line drug for osteoporosis, is bone-avid, causing side effects such as brittle and fragile bones and jaw osteonecrosis after tooth extraction. In orthodontics, active movement is precisely controlled by temporarily suppressing and resuming movement. BP impedes such control because of its long half-life of several years in bone. Therefore, we investigated the novel osteoclast-specific inhibitor reveromycin A (RMA), which has a short half-life in bone. We hypothesized that tooth movement could be precisely controlled through temporary discontinuation and re-administration of RMA. Methods Osteoprotegerin-deficient mice and wild-type mice were developed as tooth movement models under constant orthodontic force. A constant orthodontic force of 10 g was induced using a nickel-titanium closed coil spring to move the maxillary first molar for 14 days. We administered BP (1.25 mg/kg) or RMA (1.0 mg/kg) continuously and then discontinued it to reveal how the subsequent movement of teeth and surrounding alveolar bone was affected. Results Continuous BP or RMA administration suppressed osteoclast activity and preserved alveolar bone around the roots, apparently normalizing bone metabolism. Tooth movement remained suppressed after BP discontinuation but resumed at a higher rate after discontinuation of RMA. Conclusions RMA appears useful for controlling orthodontic tooth movement because it can be suppressed and resumed through administration and discontinuation, respectively. |
| Databáze: | OpenAIRE |
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