Design and biological response of doxycycline loaded chitosan microparticles for periodontal disease treatment
| Autor: | Gjorgji Petruševski, Riste Popeski-Dimovski, Nikola Geskovski, Kristina Mladenovska, Katerina Goracinova, Simona Dimchevska Sazdovska, Silvana Gjoseva |
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| Rok vydání: | 2018 |
| Předmět: |
Polymers and Plastics
Sodium chemistry.chemical_element 02 engineering and technology Doxycycline Hyclate Chitosan 03 medical and health sciences chemistry.chemical_compound Drug Delivery Systems 0302 clinical medicine Ethyl cellulose Polyphosphates Materials Chemistry Animals Humans Cellulose Periodontal Diseases Drug Carriers Coacervate Chromatography Organic Chemistry 030206 dentistry 021001 nanoscience & nanotechnology Solvent chemistry Doxycycline Spray drying Drug delivery 0210 nano-technology |
| Zdroj: | Carbohydrate Polymers. 186:260-272 |
| ISSN: | 0144-8617 |
| DOI: | 10.1016/j.carbpol.2018.01.043 |
| Popis: | The aim of this study was to develop chitosan (CS) microparticulated mucoadhesive drug delivery system (DDS) with improved therapeutic performance and biological responce. Ionotropic gelation/spray drying process was used for preparation of doxycycline hyclate (DOXY) loaded low and medium molecular weight (LMw and MMw) CS/sodium tripolyphosphate microparticles (CS/TPP MPs), further coated with ethyl cellulose (EC) using coacervation/solvent displacement technique. The relevant physico-chemical and biopharmaceutical properties were optimized using experimental design approach. Both coated and uncoated CS/TPP MPs showed high mucoadhesive potential and did not affect the viability of the tested epithelial cell line. The MPs induced slow and gradual apoptotic response in murine macrophage cell line RAW 264.7 and the observed effect depended upon formulation type and MP concentration. Biological effect of the CS-based MPs observed in our experiments point to synergism of the biological response of the carrier with the anti-inflammatory effect of DOXY. |
| Databáze: | OpenAIRE |
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