Role of S100A3 in human hepatocellular carcinoma and the anticancer effect of sodium cantharidinate
| Autor: | Wei‑Qun Yan, Zhong‑Feng Wang, Yu‑Fang He, Wen‑Yi Sun, Wei Qiu, Hai‑Jun Li, Ran Tao |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty medicine.medical_treatment Cell Liver transplantation Biology medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Immunology and Microbiology (miscellaneous) sodium cantharidinate Internal medicine medicine S100 calcium binding protein A3 Oncogene Cancer Articles hepatocellular carcinoma General Medicine Cell cycle medicine.disease Molecular medicine digestive system diseases 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Hepatocellular carcinoma Cancer research Carcinogenesis |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-1015 1792-0981 |
| Popis: | The fifth most common cancer worldwide is hepatocellular carcinoma (HCC), which has an annual mortality rate of ~800,000. Although surgical procedures for HCC, such as hepatic resection and liver transplantation, have progressed and the outcomes of patients have improved, HCC is still characterized by frequent recurrence, even after liver transplantation. In the present study the expression of the protein coding gene, S100 calcium binding protein A3 (S100A3), was observed in 62 HCC tissues and tumor-surrounding tissues. The present study indicated that S100A3 activation was involved in tumorigenesis and tumor aggressiveness. The protein and mRNA expression levels of S100A3 in the human HCC cell line (HepG2) were investigated using western blotting and reverse transcription-quantitative polymerase chain reaction analysis, respectively. The function of sodium cantharidinate in inducing HCC cell apoptosis was also investigated. Sodium cantharidinate inhibited the protein and gene expression of S100A3 in HepG2 cells in vitro. These data suggested that S100A3 has an important role in human HCC. The present study indicates that the functional properties of sodium cantharidinate are promising for the development of a novel drug that may control the expression of S100A3 and improve the treatment of human HCC in the near future. |
| Databáze: | OpenAIRE |
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